摘要
目的 探讨c erbB 2基因在结直肠癌中的表达水平及其与预后的关系。方法 利用免疫组化LSAB法检测 173例结直肠癌组织中c erbB 2基因表达水平 ,并结合长期随访资料进行分析。结果 c erbB 2基因主要为胞浆内及细胞膜表达 ,癌组织阳性率 5 2 %。c erbB 2表达阴性组 1,3,5 ,10年生存率分别为 98 7%、92 4%、87 1%和 84 1% ,弱阳性组分别为 94 5 %、76 1%、72 3%和 6 8 3% ,强阳性组分别为 91 0 %、43 5 %、36 8%和 2 3 4% ,差异有显著性 (P <0 0 0 1)。Cox回归多因素分析提示 ,c erbB 2表达水平是死亡的危险因素 ,即表达水平越高 ,预后越差。结论 c erbB 2表达水平可作为临床上预测结直肠癌预后的可靠指标 ,是影响结直肠癌预后的独立因素。
Objective To study the expression level of cerbB2 gene in colorectal cancer and its correlation to prognosis. Methods In 173 colorectal carcinoma patients, cerbB2 protein was examined immunohistochemically and patients′prognosis was evaluated by retrospective analysis combined with followup data. [WT5”HZ]Results The immunohistochemical staining of cerbB2 protein was found in the cytoplasm and membrane with a positive rate of 52% in tumor tissue. The 1, 3, 5 and 10year survival rate of patients with negative cerbB2 expression was 987%, 924%, 871% and 841% respectively; that of the patients with weakly positive cerbB2 expression was 945%, 761%, 723% and 683%, respectively. In contrast, that of patients with strongly positive cerbB2 expression was 910%, 435%, 368% and 234%, respectively. The survival rates among the three groups of patients were statistically different. Multivariate survival analysis by Cox regression model showed that cerbB2 expression level was a risky prognostic factor for colorectal cancer. Conclusion The expression level of cerbB2 protein is an independent prognostic factor in colorectal carcinoma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2001年第2期139-141,共3页
Chinese Journal of Oncology
