摘要
目的:探讨血管内皮生长因子(VEGF)与细胞增殖核抗原(Ki-67)在结肠腺癌组织中的表达情况,并分析二者表达在结肠癌发生发展中的作用。方法:应用免疫组织化学方法检测55例结肠癌组织中VEGF与Ki-67的表达情况。结果:VEGF在结肠癌中阳性率为65.4%,Ki-67增殖指数>10%的患者数为30例;VEGF及Ki-67在结肠癌组织中的表达与患者年龄、性别、肿瘤直径、肿瘤分化程度及肿瘤TNM分期均无相关性(P>0.05),与肿瘤发生淋巴结转移有相关性(P<0.05)。相关分析显示,结肠癌组织中VEGF与Ki-67表达呈显著正相关(r=0.335,P=0.012)。结论:VEGF和Ki-67阳性表达的结肠癌患者比二者单独阳性表达的患者预后差,二者联合检测对判断结肠癌的预后有一定的价值。
Objective ：To explore the expression of vascular endothelial growth factor （VEGF） and Ki-67 in colon cancer tissue and to analyze the role of development in both of the expressions. Methods： Immunohistochemical method was used to detect VEGF and Ki-67 expression about the recent collection of 55 colon cancer tissues. Results：The positive rate of VEGF was 65.4% in colon cancer. And the condition of 30 cases was more than 10% of proliferation index of Ki-67. VEGF and Ki-67 were no difference among age, sex, diameter, differentiation degree and TNM staging of tumor （P 〉 0.05 ） , but were significant difference with lymph node metastasis （ P 〈 0.05 ）. There was significant correlation between VEGF and Ki-67 expression with correlation analysis （r = 0.335, P = 0.012）. Conclusion： The prognoses of patients of positive expression of VEGF and Ki-67 were worse than the separate positive expression of them. For judging the prognosis of colon cancer, to detect the two simultaneously has a certain value.
出处
《山西职工医学院学报》
CAS
2011年第3期4-6,共3页
Journal of Shanxi Medical College for Continuing Education
