摘要
目的研究分化抑制因子2（Id2）、表皮生长因子受体（EGFR）及人类表皮生长因子受体2（Her-2）在结直肠癌中的表达以及与患者预后的关系。方法采用PV6000二步法检测359例结直肠癌及35例癌旁正常组织中Id2、EGFR及Her-2的表达。结果（1）结直肠癌组织中Id2的阳性率为68．0％，EGFR的阳性率为64．9％，二者在结直肠癌组织中的表达均显著高于癌旁正常组织中的表达（P值均〈0．05）。Her-2在结直肠癌组织中的阳性率为1．7％，与癌旁正常组织中的阳性率相比差异无统计学意义（P=0．441）。（2）Id2的阳性表达与患者的TNM分期、组织学分级、肿瘤组织的肠壁浸润深度、淋巴结转移情况以及腹腔和远处转移情况等相关（P值均〈0．05）。（3）Id2阳性表达组的无瘤生存时间较阴性表达组短（P=0．002），阳性表达组的5年生存率低于阴性组（P=0．001）。结论Id2可能在结直肠癌的发生、发展及转移中发挥重要作用，可以作为评价结直肠肿瘤生物学行为及判断预后的指标之一。
Objective To study the correlations of Id2, EGFR, Her-2 expressions with tumor biological characteristics, postoperative disease-free survival （DFS） and overall survival （OS） in patients of colorectal carcinoma. Methods Immunohistochemistry PV6000 method was used to test Id2, EGFR and Her-2 expressions in paraffin-embedded colorectal carcinoma tissues of 359 cases and paracancerous normal mucosa of 35 cases. Results In this study 198 cases were followed up. The positive expression rate of Id2, EGFR and Her-2 in colorectal carcinoma was 68.0%, 64.9% and 1.7% respectively. Id2 expression was related to clinical stage, invasion, differentiation degree, lymphatic invasion and distant metastasis （P 〈 0.05 ）. The five-year survival rate of patients with expression of Id2 was lower than that with negative expression （P = 0. 001 ）. The expression of Id2 and EGFR in carcinoma was significantly higher than that in normal mucosa beside tumors （P 〈 0. 05 ）. Conclusions Id2 may play a .significant role in the pathogenesis of colorectal carcinoma and may be used as a predictor for tumor biological behavior and prognosis in patients with colorectal carcinoma.
出处
《中华普通外科杂志》
CSCD
北大核心
2008年第2期104-107,共4页
Chinese Journal of General Surgery
关键词
结直肠肿瘤
受体
表皮生长因子
病理学
临床
分化抑制因子
Colorectal neoplasms
Receptor, epidermal growth factor
Pathology, clinical
Inhibitor of DNA binding
