摘要
目的:探讨重组人生长激素在治疗老年男性慢性心力衰竭时对血脂代谢的影响。方法:将对87例老年慢性心力衰竭患者随机分别进行常规心力衰竭治疗组(CHF对照组)(n=46)和常规治疗基础上加用生长激素治疗组(CHF实验组)(n=41)及正常对照组(n=10);均连续治疗3个月,观察治疗前后生长激素(GH)、(胰岛素样生长因子-1(IGF-1)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC)等各项指标的变化。结果:治疗前,各组之间GH、IGF-1水平无明显差异。治疗后,CHF实验组患者GH(0.71±0.34 vs 0.96±0.48)、IGF-1(95.64±21.11 vs 111.64±23.14)水平较治疗前明显升高,CHF对照组治疗前后GH(0.81±0.32 vs 0.79±0.29)、IGF-1(97.82±19.74 vs 99.65±20.11)水平无明显差异。治疗后CHF实验组与CHF对照组相比GH(0.96±0.48 vs 0.79±0.29)、IGF-1(111.64±23.14 vs 99.65±20.11)水平显著升高(P<0.05)。治疗前,3组患者血脂各项指标无明显差异(P>0.05),治疗后,CHF实验组LDL-C(2.11±0.82 vs 1.76±0.51)、TC(3.78±1.34 vs 3.21±1.17)水平较治疗前有所下降(P<0.05),而HDL-C(1.10±0.31 vs 0.99±0.28)、TG(1.89±1.07 vs 1.66±0.95)水平较治疗前无显著差异(P>0.05)。然而,CHF对照组治疗前、后相比,LDL-C、HDL-C、TC、TG水平无显著差异(P>0.05)。结论:应用重组人生长激素治疗老年慢性心力衰竭,GH参与了血脂代谢,可降低LDL-C、TC水平,但对HDL-C、TG水平无明显影响。故在长期应用生长激素时需要关注血脂代谢,及时调整血脂治疗。
Objective： To investigate the effects of recombinant human growth hormone on serum lipid in aged male patients with chronic heart failure （CHF）. Methods： Eighty seven patients with chronic heart failure（≥60 years old）were randomly divided into 2 groups： the CHF control group （ n = 46）who received regular therapy and the CI-IF experimental group （ n = 41 ）who received regular therapy and recombinant human growth hormone. The treatment would be continued for 3months. Another group was normal control group （ n = 10）. The detection of serum growth hormone （GH）, insuhn-like growth factor （IGF-1 ）, total cholesterol （TC）, triglyceride（TG）, low-density lipopretein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C） was carried out before and after treatment in the participants. Results： Before treatment, the levels of GH and IGF-1 were not significantly different among groups. After treatment, the levels of GH （0.71 ± 0.34 vs 0. 96 ± 0.48）and IGF-1（95.64 ± 21.11 vs 111.64± 23.14）in CHF experimental group were higher than those before the treatment. In CHF control group, the levels of GH（0.81 ± 0. 32 vs 0. 79 ± 0.29 ） and IGF- 1 （ 97.82 ± 19.74 vs 99.65 ± 20.11 ） had no significant change after the treatment. After treatment, the levels of GH（0.96 ± 0.48 vs 0. 79± 0.29） and IGF- 1 （ 111.64 ± 23.14 vs 99.65 ±20.11 ） in CHF experimental group were higher compared with that of CI-IF control group. Before treatment, the serum levels of LDL-C, I-1DL-C, TC and TG had no significant difference among groups. Mter treatment,the levels of LDL-C（2.11 ±0.82 vs 1.76± 0.51）and TC（3.78± 1.34 vs 3.21 ± 1.17）in CI-IF experimental group were lower than those before the treatment. However, the levels of HDL-C（ 1.10± 0.31 vs 0. 99± 0.28） and TG（ 1. 89 ± 1.07 vs 1.66± 0.95） had no significant change after the treatment compared with before treatment. In CHF control group, the sermn hpid levels had no significant cha
出处
《中国应用生理学杂志》
CAS
CSCD
2014年第3期247-250,共4页
Chinese Journal of Applied Physiology
