摘要
目的:探讨重组人生长激素(rhGH)对慢性阻塞性肺疾病(COPD)伴自发性气胸患者的治疗效果。方法:58例COPD伴自发性气胸患者随机分为治疗组与对照组,每组29例。对照组给予抗感染、氧疗、营养支持等常规治疗;治疗组在常规治疗基础上应用小剂量rhGH0.1IU.kg-1.d-1,于入院后第2天起每晚皮下注射,疗程7d。观察2组留置胸管时间、住院时间,以及治疗前后体质量指数(BMI)、血清生长激素(GH)、胰岛素样生长因子-1(IGF-1)、白蛋白(ALB)。结果:治疗组与对照组的留置胸管时间分别为(5.5±1.8)、(9.3±2.2)d(P<0.05),住院时间分别为(19.4±4.2)、(26.8±5.0)d(P<0.05)。治疗前2组BMI、ALB、GH、IGF-1差异无统计学意义(P>0.05);治疗组治疗后以上各项指标均较对照组治疗后高,差异有统计学意义(P<0.05)。结论:rhGH能改善COPD伴自发性气胸患者的营养状态,缩短患者留置胸管时间、住院时间,促进患者康复。
OBJECTIVE： To investigate the therapeutic efficacy of recombination human growth hormone （rhGH） on the patients with chronic obstructive pulmonary disease （COPD） complicated with spontaneous pneumothorax （SP）. METHODS： 58 patients with COPD complicated with SP were randomly divided into two groups： 29 cases in the control group received conventional therapy including anti - infection therapy, oxygen therapy and nutritional support, and another 29 in the trial group received low dose of rhGH （0.1 U · kg ^-1 · d^-1） hypo quaque nocte for 7 days started from the second day after admission in addition to the conventional therapy as employed for control group. The time of chest tube stay and the length of hospital stay were compared between the two groups. The body mass index （BMI） and serum levels of growth hormone （GH）, in- sulinlike growth factor- 1 （IGF- 1） and albumin （ALB） were measured in all cases before and after treatment. RESULTS： The time of chest tube stay and the length of hospital stay in the trial group vs. the control group were （5.5 ± 1.8）d vs. （9.3±2.2） d （ P 〈 0.05） and （ 19.4 ± 4.2） d vs. （26.8 ± 5.0） d （P 〈 0.05）, respectively. No significant differences were noted between the two groups before treatment in BMI, ALB, GH and IGF-1 （P 〉 0.05）; however, after treatment, all indexes （BMI, ALB, GH and IGF- 1） were higher in the trial group than in the control group（P 〈 0.05）. CONCLUSION： It has been proved that rhGH can improve the nutritional status, shorten the time for chest tube stay and length of hospital stay, and promote recovery for patients with COPD complicated with SP.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第14期1086-1088,共3页
China Pharmacy
关键词
重组人生长激素
慢性阻塞性肺疾病
自发性气胸
治疗效果
营养状况
生长激素
胰岛素样生长因子-1
Recombination human growth hormone
Chronic obstructive pulmonary disease
Spontaneous pneumothorax
Therapeutic efficacy
Nutritional state
Growth hormone
Insulin-like growth factor- 1
