摘要
目的探讨结直肠癌患者术前血清癌胚抗原(CEA)和糖类抗原19-9(CA19-9)检测结果与结直肠癌临床病理分期的相关性及其临床意义。方法收集2011年4月至2013年1月于重庆医科大学附属第一医院行结直肠癌手术治疗的231例患者的病历资料,将患者术前CEA和CA19-9的检测结果与其术后临床病理分期结果及临床资料的相关性进行统计分析。结果结直肠癌患者中CEA总阳性率为51.5%(119/231),CA19-9总阳性率为46.3%(107/231)。结直肠癌患者中CEA阳性率和CA19-9阳性率均与肿瘤TNM分期和肿瘤临床分期呈正相关(P<0.05)。结论 CEA和CA19-9的阳性率与结直肠癌的进展和转移密切相关;术前血清CEA和CA19-9检测可以作为结直肠癌患者临床分期的辅助指标,并可以在一定程度上指导结直肠癌患者治疗和判断结直肠癌患者预后。
Objective To approach the correlation between preoperative detection of serumal carcinoembryonic antigen （CEA ） and carbohydrate antigen 19‐9（CA19‐9） and primary tumor/regional lymph nodes/distant metastasis（TNM） staging ,clinicopatho‐logic staging and clinical features of patients with colorectal cancer （CRC） ,and to explore their clinical significance .Methods The dates of 231 patients with CRC treated in the First Affiliated Hospital of Chongqing Medical University from April 2011 to January 2013 were gathered .Then ,the relationship between detection of CEA and CA19‐9 and TNM staging ,clinicopathologic staging and clinical features of patients with CRC were analyzed . Results The positive rate of CEA in patients with CRC was 51 .5%（119/231） and the positive rate of CA19‐9 in patients with CRC was 46 .3% （107/231） .The positive rates of CEA and CA19‐9 were positively correlated with the TNM staging and clinicopathologic staging of CRC （P〈0 .05） .Conclusion The positive rate of CEA and CA19‐9 were associated with the tumor progress and metastasis ,so the detection of CEA and CA19‐9 could be used as one of important serumal marker for clinicopathologic staging of CRC .Also ,detection of CEA and CA19‐9 could be used for prog‐nosis judgment and therapeutic schedule institution .
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第14期1710-1712,1715,共4页
Chongqing medicine
