摘要
目的探讨结直肠癌患者术前血清CA19-9、CEA、TPS水平与患者年龄、性别、肿瘤位置、分化程度、侵袭深度、淋巴结转移、远处转移及肿瘤的TNM分期的相关性。方法回顾性分析中国医学科学院肿瘤医院2010年施行手术的615例结直肠癌患者的临床病理资料,应用χ2检验及t检验从阳性率及数值两个方面进行相关性分析。结果血清CA19-9与CEA对结直肠癌的术前分期意义较大,可预测肿瘤的侵润深度、淋巴结转移情况及是否有脉管瘤栓,进而预测疾病的预后。并且阳性率的比较比绝对数值的观察更有价值。对于早期(0期、Ι期)患者,TPS阳性率较CA19-9和CEA明显偏高,因此对于发现早期病变更有价值。联合检测能明显提高疾病的检出率。结论结直肠癌患者术前的血清CA19-9、CEA、TPS水平有助于患者的术前分期及预后的预测,应作为常规检查指标并联合应用。
Objective To assess the correlation of colorectal cancer patients’ preoperative serum CA19-9,TPS,CEA levels with patients’ age,gender,tumors’ differentiation,location,depth of invasion, lymph node metastasis,distant metastasis and TNM stages etc.Method Retrospectively analyze clinical and pathological data of 615 colorectal cancer patients who underwent operations in Chinese Academy of Medical Sciences Cancer Hospital in 2010 applyingχ2 test and t-test.Results Serum CA19-9 and CEA level were of greater significances in preoperative staging for patients with colorectal cancer,and could predict the depth of tumor invasion,lymph node metastasis,and vascular invasion,so as to predict the prognosis.And compared with value, positive rate is more valuable.For early stage ( 0,Ιperiod ) patients, TPS positive rate is significantly higher than the other two markers,so it is more sensitive for the early detection of the disease. Combined application can significantly improve the detection rate of the disease.Conclusion Preoperative serum CEA, CA19-9 and TPS levels of colorectal cancer patients contribute to preoperative staging and prognosis predicting,and should be routinely examined and combinedly applied.
出处
《中华结直肠疾病电子杂志》
2013年第5期230-233,共4页
Chinese Journal of Colorectal Diseases(Electronic Edition)
关键词
结直肠肿瘤
肿瘤分期
抗原
肿瘤相关
碳水化合物
癌胚抗原
Colorectal neoplasms
Neoplasm staging
Antigens,tumor-associated,carbohydrate
Carcinoembryonic antigen
