摘要
目的探讨血清白细胞介素6(IL-6)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)的水平在胃癌患者诊治中的意义。方法用化学发光免疫法测定40例胃癌患者IL-6、CEA、CA19-9的水平,并设30例健康体检者为对照组。结果胃癌患者血清IL-6、CEA、CA19-9的水平均显著高于健康对照组,差异有统计学意义(分别为P<0.01、P<0.05、P<0.01);CEA阳性组的IL-6阳性率明显高于CEA阴性组,分别为78.57%和19.23%,差异有统计学意义(P<0.01);CA19-9阳性组的IL-6阳性率明显高于CA19-9阴性组,分别为81.25%和12.50%,差异有统计学意义(P<0.01)。结论IL-6可以与CEA、CA19-9一同作为有效的肿瘤标志物,在胃癌的诊断、监测和预后判断等方面具有一定的临床应用价值。
Objective To investigate the diagnostic value of serum interieukin--6（IL-6）,carcinoembryonic antigen（CEA）,carbohydrate antigen-19-9（CA19-9） in patients with gastric cancer. Methods The IL-6,CEA,CA19-9 levels of 40 cases of the patients with gastric cancer were measured with chemiluminescent immunoassay, and a healthy group was set up. Results The serum levels of IL-6,CEA,CA19-9 in patients with gastric cancer were sig- nificantly higher than that in normal controls group （P〈0.01,P〈0. 05,P〈0. 01）; The positive rate of IL-6 in the group with positive expression of CEA was significantly higher than that in the group with negative expression of CEA, with the rate of 78.57 % and 19.23 % （P（0. 01）respectively; The positive rate of IL-6 in the group with positive expression of CA19-9 was significantly higher than that in the group with negative expression of CA19-9, with the rate of 81.25% and 12.50% （P〈0.01） respectively. Conclusion IL-6 together with the CEA,CA19-9 can be regarded as an effective tumor marker that has some clinical value in the diagnosis,monitoring and prognosis of gastric cancer.
出处
《检验医学与临床》
CAS
2009年第17期1413-1414,共2页
Laboratory Medicine and Clinic
关键词
胃癌
白细胞介素-6
癌胚抗原
糖类抗原19—9
gastric cancer
interieukin 6 （IL-6）
carcinoembryonic antigen（CEA）
carbohydrate antigen-19-9（CA19-9）
