期刊文献+

血根碱抗肿瘤作用研究进展 被引量:6

Progress on Anti-tumor Effect of Sanguinarine
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摘要 血根碱(Sanguinarine)是一种苯菲啶异喹啉类生物碱,具有抗菌、消炎镇痛、抗肿瘤及杀虫等作用,已经作为一种新型药物用于医学和农业生产。论文主要介绍了血根碱抗肿瘤作用的研究概况,并对其作用机理进行了探讨,以期为该药在临床中的合理应用提供参考。 Sanguinarine is a benzene phenanthridine isoquinoline alkaloid which can anti-bacterial,anti-in-flammatory,anti-tumor,insecticidal effects and can induce apoptosis,and has been as a new type of drug in medicine and agricultural production.This review summarized research progress of sanguinarine on anti-tumor effects and its mechanism,which could provide a reference for the application of sanguinarine in clinical.
出处 《动物医学进展》 CSCD 北大核心 2014年第5期105-107,共3页 Progress In Veterinary Medicine
基金 作物种质创新与资源利用重点实验室科学基金项目(12KFXM02) 湖南省科技计划重点项目(2012FJ2015)
关键词 血根碱 抗肿瘤 作用机理 sanguinarine antitumor effect action mechanism
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参考文献20

  • 1Ahmad N, Gupta S, Husain M M, et al. Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells [J]. Clin Cancer Res, 2000, 6 (4): 1524- 1528. 被引量:1
  • 2Tsukamoto H, Kondo S, Mukudai Y, et al. Evaluation of anticancer activities of benzo phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line [J]. Anticancer Res, 2011,31(9):2841-2846. 被引量:1
  • 3Lee J S, Iung W K, Jeong M H, et al. Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway [J]. Int J Toxicol , 2012, 31(1) :70-77. 被引量:1
  • 4Park H, Bergeron E, Senta H, et al. Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways [J]. Biochem Biophys Res Commun , 2010, 399(3) : 446-451. 被引量:1
  • 5Aburai N, Yoshida M, Ohnishi M, et al. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells [J]. Biosci Biotechnol Biochem , 2010, 74(3): 548-552. 被引量:1
  • 6Chang M C, Chan C r. Wang Y J, et al. Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization [J]. Toxicol Appl Pharmacol, 2007, 218(2) : 143-15l. 被引量:1
  • 7Burgeiro A, Bento A C, Gajate C, et al. Rapid human melanoma cell death induced by sanguinarine through oxidative stress [J]. EurJ Pharmacol, 2013, 705(1-3):109-118. 被引量:1
  • 8Pica F, Balestrieri E, Serafino A, et al. Antitumor effects of the benzophenanthridine alkaloid sanguinarine in a rat syngeneic model of colorectal cancer [J]. Anticancer Drug, 2012, 23 (1) :32-42. 被引量:1
  • 9Sun M, Lou W, Chun J Y, et al. Sanguinarine suppresses prostate tumor growth and inhibits survivin expression [J]. Genes Cancer, 2010, 1(3) :283-292. 被引量:1
  • 10Debiton E, Madelmont J C, Legault J, et al. Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion [J]. Cancer Chemother Pharmacol, 2003, 51(6) :474-482. 被引量:1

二级参考文献6

  • 1郁建平,赵东亮,孟祥斌,周晓秋.博落回生物碱对8种真菌的抑菌作用[J].山地农业生物学报,2006,25(1):89-91. 被引量:37
  • 2Drsata J,Ulrichová J,Walterová D.Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase.J Enzyme Inhibit,1996,10:231-237. 被引量:1
  • 3European Commission.Cummunity register of feed additives pursuant to regulation No 1831.2003[S].November,2006,Rev 6. 被引量:1
  • 4Tschirner K,Susenbeth A,S Wolffram.Influence of Sangrovit supplementation on nitrogen balance and feed intake in growing pigs.Vitamins and additives in nutrition of man and animal,Jena/Thuringia,Germany.(Abstr.)Friedrich Schiller Univ Jena,Jena,Germany.2003,P45 in 9th Syrup. 被引量:1
  • 5.兽药质量标准[S].[S].中华人民共和国农业部,2003年版.145. 被引量:14
  • 6饶茂阳,郁建生.禽痢净口服液的临床效果观察[J].中兽医医药杂志,2001,20(4):17-18. 被引量:11

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