摘要
目的分析血清肿瘤标志物测定在肺癌诊断中的意义。方法选取2011年2月至2013年6月间80例肺癌患者为研究组,80例肺部良性疾病患者为良性对照组,40例健康人群为健康对照组。比较血清肿瘤标志物CYFRA21-1、NSE、CA125和CEA检测结果。结果研究组CYFRA21-1、NSE、CA125和CEA水平显著高于良性组和健康组,差异有统计学意义(P<0.05)。其中CYFRA21-1、NSE、CEA分别在肺鳞癌、小细胞肺癌、肺腺癌中表达水平最高(P<0.05),CA125表达差异无统计学意义(P>0.05)。CYFRA21-1、NSE、CA125和CEA联合检测的灵敏度显著高于单项检测,差异有统计学意义(P<0.05)。结论血清肿瘤标志物CYFRA21-1、NSE、CA125和CEA的测定在肺癌诊断中具有重要价值,联合检测的灵敏度较高,辅助价值大。
Objective To analyze values of the measurement of serum tumor markers in the diagno- sis of lung cancer. Methods 80 patients with lung cancers admitted to our hospital from the February 2011 to June 2013 were selected as the study group and analyzed retrospectively,80 cases with benign lung dis- ease as benign control group, and 40 healthy people as healthy control group, serum tumor markers CY- FRA21-1 ,NSE,CA125 and CEA were measured and compared. Results Four serum tumor markers in the study group was significantly higher than the level of detection of benign group and healthy group, the differ- ence was statistically significant （P 〈 0. 05 ） ;The highest expression level of CYFRA21-1, NSE, CEA in lung squamous cell carcinoma, small cell lung cancer and pancreas cancer respectively was significantly different from other types of cancer （P 〈0. 05）. CA125 showed no difference （P 〉0. 05）. The sensitivity of com- bined detection of four serum tumor markers was significantly higher than that of single detection （ P 〈 0. 05）. Conclusion Serum tumor markers CYFRA21-1 ,NSE,CA125 and CEA determination for auxiliary diagnosis of lung cancer has important clinical value. The combined detection owns higher sensitivity and lar- ger secondary value.
出处
《中国肿瘤临床与康复》
2014年第4期419-421,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
血清肿瘤标志物
联合检测
肺肿瘤
价值
Serum tumor markers
Joint detection
Lung neoplasms
Value
