摘要
目的探讨血清肿瘤标记物鳞状细胞癌相关抗原(SCC-Ag)、细胞角蛋白19血清片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)在肺癌临床诊断中的价值。方法采用酶联免疫法检测99例肺癌病人及48例肺良性病变病人血清SCC-Ag、CYFRA21-1、NSE和CEA的水平。结果肺癌组血清四项肿瘤标记物的含量均高于肺良性病变组(P<0.01)。SCC-Ag水平在肺鳞癌中明显升高;CYFRA21-1水平以非小细胞肺癌(NSCLC)升高明显;NSE以小细胞肺癌(SCLC)升高为明显;CEA以肺腺癌增高为主;SCC-Ag、CYFRA21-1、NSE、CEA及四项联合检测诊断肺癌的灵敏度分别为60·47%、59·45%、45·69%、69·68%、97·83%,特异度分别为93·69%、90·57%、93·85%、93·67%、81·36%,准确率分别为71·56%、68·58%、61·79%、69·57%、81·95%。结论SCC-Ag对鳞癌、CYFRA21-1对非小细胞肺癌(NSCLC)、NSE对小细胞肺癌(SCLC)、CEA对腺癌具有较大的辅助诊断价值,四项联合检测提高肺癌诊断的灵敏度、准确率。
Objective To appraise the values of tumor markers of SCC-Ag, CYFRA21-1, NSE and CEA in the diagnosis of lung cancer. Methods The levels of SCC-Ag, CYFRA21-1, NSE and CEA were measured by dectrochemiluminescenee in serum of 99 patients with lung cancer and 48 patients with benign lung diseases. Results The levels of SCC-Ag, CYFRA21-1, NSE and CEA in cancer patients were significantly higher than that of the patients with benign ones （P 〈0. 01 ）. In comparison with patients with benign rumor, those lung cancer patients showed the following features ： The rise of SCC-Ag was most obviously in squamons cell carcinoma, the level of CYFRA21-1 was manifested in higher value in NSCLC ; NSE increased obviously in SCLC and the increase of CEA was higher in adenocar- einoma. The sensitivity values of SCC-Ag, CYFRA21-1, NSE, CEA and the combined determination containing four tumor markers were, respectively, 60. 47%, 59. 45%, 45.69%, 69. 68%, 97.83% ; the respective specificity values were 93.69% ,90. 57% ,93.85%, 93. 67% ,81.36% ; and the respective effectiveness rates were 71.56% ,68. 58% ,61.79% ,69. 57% ,81.95%. Conclusion SCC-Ag, CYFRA21-1, NSE and CEA in serum have the important diagnostic values in detecting lung cancer. A combination of multiple tumor markers may increase diagnostic value of the disease in terms of its sensitivity and effectiveness.
出处
《临床肺科杂志》
2007年第2期111-112,共2页
Journal of Clinical Pulmonary Medicine
