摘要
人β-防御素(humanβ-defensin,HBD)是由人体细胞产生的一类抗菌肽,它对细菌、真菌和病毒等都具有较强的抑制作用,应用前景广阔,有望通过基因工程重组表达技术开发成为一类新型的抗感染药物。本文从HBD的结构、表达部位、原核与真核表达系统、表达技术和方法等方面对HBD研究状况进行了综述,以期为人β-防御素的研究和应用提供参考。
Human 13-defensins are a kind of polypeptide substances with biological activity produced by human and have a powerful killing effect on bacteria, fungi, viruses, etc. It is expected to become the development of a new class of anti-infective drugs and have a wide application prospect. Genetic engineering technology is the most economic, scientific and effective way to obtain a lot of human B-defensins. In this communication, the progress in the structural characteristics, prokaryotic expression and eukaryotic expression systems, and expression technology of human B-defensins are reviewed. The results provide reference for their further development and utilization.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2014年第4期402-408,共7页
Chinese Journal of Zoonoses
基金
陕西省科技厅项目(2012K01-38)
陕西省教育厅科学研究计划项目(12JK0840)
汉中市科技计划项目(2013FZ27)联合资助~~
关键词
人B-防御素
基因工程
原核表达
真核表达
human ^-de^ensins
genetic engineering
prokaryotic expression
eukaryotic expression
