摘要
目的探讨二甲双胍联合甲钴胺治疗2型糖尿病周围神经病变的临床效果。方法选取本院2009年4月～2012年4月收治的糖尿病周围神经病变患者172例，将其随机分为治疗组和对照组，每组86例。治疗组采用二甲双胍联合甲钴胺进行治疗，对照组采用瑞格列奈联合甲钴胺进行治疗。观察比较两组治疗前后的空腹血糖（FBG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbAlc）、丙二醛（MDA）、超氧化物歧化酶（SOD）、总抗氧化能力（TAOC）等指标。结果治疗后，治疗组FBG、2hPG、HbAlc水平及MDA、SOD、TAOC水平均显著优于对照组．差异有统计学意义（P〈0．05）。结论二甲双胍联合甲钴胺治疗2型糖尿病周围神经病变临床效果较好，是安全可靠的选择。
Objective To explore the efficacy of metformin combined with methylcobalamin in treatment of peripheral neuropathy in patients with type 2 diabetes.Methods 172 cases of patients with diabetic peripheral neuropathy admit- ted to our hospital from April 2009 to April 2012 were selected,and were randomly divided into treatment group and control groups of 86 cases.Metformin combined with mecobalamin was used to the treatment group,nateglinide combined with mecobalamin was used to the control group.Fasting blood glucose （FBG）,2 h postprandial blood glucose （2hPG）, HbAlc,malondialdehyde （MDA）,superoxide dismutase （SOD）,total antioxidant capacity （TAOC） was compared before and after treatment in two groups respectively.Results After treatment,the FBG,2hPG,HbAlc,MDA,SOD,TAOC in treatment group was significantly better than that in the control group respectively, the difference was significant （P〈0.05）.Conclusion The efficacy of metformin combined with methylcobalamin in treatment of peripheral neuropathy in patients with type 2 diabetes is better,is a reliable choice.
出处
《中国当代医药》
2014年第12期73-74,76,共3页
China Modern Medicine
