摘要
目的探讨盐酸二甲双胍片治疗2型糖尿病神经病变患者的疗效。方法治疗组采用盐酸二甲双胍片联合甲钴胺片进行治疗;对照组采用那格列奈片联合甲钴胺片进行治疗,比较两组患者疗效。结果治疗组空腹血糖(FBG)、餐后2 h血糖(PBG)及糖化血红蛋白(HbA1c)较对照组有显著下降,正中神经和腓总神经的运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)与对照组比较有显著增加,丙二醛(MDA)、超氧化物歧化酶(SOD)、总抗氧化能力(TAOC)与对照组相比有显著改善,总有效率为93.3%。结论盐酸二甲双胍片联合甲钴胺片治疗2型糖尿病神经病变,疗效确切。
Objective To study the efficacy of metformin hydrochloride tablets on type 2 diabetic patients with neuropathy. Methods The experimental group treated with the therapy of metformin hydrochloride tablets and mecobal- amin tablets. The control group treated with the therapy of nateglinide tablets and mecobalamin tablets. The clinical effects were observed and compared. Results The FBG, PBG and HbAlc had a significant decrease in in the experimental group compared with the control group.The MNCV and SNCV in median nerve and peroneal nerve had a signif- icant increase in the experimental group compared with the control group. The MDA, SOD and TAOC had a significant improvement in the experimental group compared with the control group. The total efficiency in experimental group was 93.3%. Conclusion The therapy of metformin hydrochloride tablets and mecobalamin tablets in type 2 diabetic patients with neuropathy was efficacy.
出处
《中国现代医生》
2013年第8期27-28,31,共3页
China Modern Doctor
关键词
盐酸二甲双胍片
2型糖尿病神经病变
氧化应激
Metformin hydrochloride tablets
Type 2 diabetic patients with neuropathy
Oxidative stress
