摘要
目的:通过比较亚低温处理以及常规处理对重型颅脑损伤(sTBI)合并急性创伤性凝血病(ATC)患者的临床治疗效果,研究亚低温处理对sTBI合并ATC的临床应用价值。方法:选取sTBI合并ATC患者100例,随机分为实验组和对照组,实验组患者采取亚低温处理,对照组患者采取常规处理。测量实验组和对照组患者在不同阶段的血浆纤维蛋白原(FIB)、血浆凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及D-二聚体(D-D)水平,同时对患者的生命体征、血氧饱和度、血电解质、血气、颅内压及并发症情况进行检测记录。结果:经亚低温处理后实验组患者的FIB、TT、APTT、PT、D-D水平以及生命体征、血氧饱和度、血电解质及血气指标等与对照组患者无显著差异;但实验组患者的颅内压治疗1 d、3 d和5 d后均显著低于对照组,其差异有统计学意义(t=4.76,t=9.87,t=8.92;P<0.01)。结论:sTBI合并ATC患者采用亚低温处理与常规处理相比不会带来风险,而且还能显著降低患者的颅内压,对患者脑组织起到保护作用。
Objective：To compare hypothermia treatment and conventional treatment for severe traumatic brain injury patients with acute traumatic coagulopathy the clinical therapeutic effect of hypothermia treatment to explore the clinical value.Methods： A hospital sTBI merger ATC 100 patients were randomly divided into experimental and control groups, the experimental group were taken hypothermia treatment in the control group of patients taking conventional treatment. Measuring experimental group and control group of patients at different stages of FIB, TT, APTT, PT, and D-dimer levels, while the patient＆#39;s vital signs, oxygen saturation, blood electrolytes, blood pressure, intracranial pressure and complications testing records.Results： The results showed that the experimental group were FIB, TT, APTT, PT, D-dimer levels and vital signs, oxygen saturation, serum electrolytes, blood gas analysis and other patients with no significant difference between the control group; However, the experimental group of patients with intracranial pressure was significantly lower than the control group（t=4.76,t=9.87,t=8.92;P＆lt;0.01）.Conclusion： sTBI combined use of mild hypothermia treatment in patients with ATC compared to conventional treatment does not pose a risk, but it also significantly lower in patients with intracranial pressure, brain tissue of the patient play a protective role.
出处
《中国医学装备》
2014年第4期98-100,共3页
China Medical Equipment
关键词
亚低温
重型颅脑创伤
急性创伤性凝血病
应用价值
Mild hypothermia
Severe head trauma
Acute traumatic coagulopathy
Application value
