摘要
目的研究亚低温治疗对重型颅脑损伤后患者血清抗脑抗体浓度和C反应性蛋白的含量影响,进一步探讨亚低温脑保护作用的机制。方法该实验选择80例sTBI住院患者。分成常温治疗(NT)组和亚低温治疗(HT)组各40例,分别予以常温治疗和亚低温治疗,两组患者均于伤后第1、3、5、7和14天采用酶联免疫吸附(ELISA)法测定血清抗脑抗体含量,免疫速率散射比浊法测定血清CRP水平。并比较两组患者的临床预后,另取该院门诊正常体检者16例作为对照组,正常对照组血清标本采集及保存方法与病例组相同。结果研究者发现HT后各时点HT组血清抗脑抗体浓度C反应性蛋白(CRP)含量低于NT组,且差异有统计学意义(P<0.01)。格拉斯哥预后评分显示出院时HT组预后较NT组为佳。结论 HT能够降低sTBI患者测定血清抗脑抗体和C反应性蛋白(CRP)含量,能改善预后,具有脑保护作用。
【Objective】To determine the effect of hypothermia on serum levels of ABAb and CRP after traumatic brain injury,disclose the probably protective mechanism of mild hypothermia.【Methods】A total of 80 cases with sTBl were treated with normothermia-treated（NT） and mild hypothermia（HT）,respectively.ELISA was used to measure serum levels of ABAb and CRP levels were detected by the immune rate nephelometry.At 1,3,5,7 and 10 days after injury the changes of ABAb and CRP in serum and the influence of each group were observed.Contrast clinical prognosis of patients in the two groups was used to research the protective mechanism of mild hypothermia protecting on patients with sTBI.16 serum specimens of normal persons were used as control group,the collection and conservation of normal specimens were the same as those of the sTBI patients.【Result】The concentration of anti-brain antibodies and CRP levels in the serum of HT group were lower than those of NT group,and the difference between the unified total significance（P 0.01）,and（Glasgow outcome scale） GOS discharged the HT group prognosis was better than the NT group.【Conclusion】HT can reduce sTBI patients with serum anti-brain antibodies and CRP levels,improve the prognosis with a brain protective effect.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第28期3510-3514,共5页
China Journal of Modern Medicine
