摘要
目的：探讨脑源性神经营养因子在脑缺血损伤修复反应中的临床应用。方法：将成年大鼠随机分为5组，各10例，包括对照组、大鼠缺血2h后进行再灌注6h组、12h组、24h组和72h组，分别进行脑缺血动物模型建立及灌注、染色观察。结果：经灌注后各组患鼠的BDNF细胞阳性数均明显高于对照组，数据经统计学比较具有显著差异（P〈0．05）；且随着灌注时间的延长，BDNF细胞阳性数量在24h以内均呈上升趋势。结论：BDNF对于脑缺血梗死周围组织的修复有重要作用。
Objective：To discuss the clinical restoration effects of brain--derived neurotrophic factor （BDNF） in cerebral ischemia damage. Methods：The adult rats were divided into 5 groups,including Control Group, 6h Group, 12h Group, 24h Group and 72h Group. Separately making the animals of＇cerebral ischemia with model,perfusion and staining. Results：The BDNF positive cells after perfusion were significantly higher than Control Group （P〈0. 05）. BDNF positive cells showed and upward trend within 24 hours after perfusion. Conclusion：It had important＇effects of brain--derived neurotrophic factor （BDNF） in cerebral ischemia damage.
出处
《按摩与康复医学》
2011年第15期28-29,共2页
Chinese Manipulation and Rehabilitation Medicine
关键词
脑源性神经营养因子
脑缺血损伤
临床作用
Brain--derived Neurotrophic Factor Cerebral Ischemia Damage Clinical Effects
