摘要
【摘要】目的探讨肥胖及超体质量对普通肺炎患儿平均住院时间及总病程的影响。方法共有455例2—7岁普通肺炎患儿纳入本研究，包括147例肥胖儿童、141例超体质量儿童以及167例正常体质量儿童。然后根据年龄进一步分为t〉2～4岁年龄组和≥4～7岁年龄组。通过查阅病历管理系统，收集患儿资料，包括性别、年龄、体质量、身高、住院时间、总病程、外周血细胞计数（白细胞、中性粒细胞、单核细胞及淋巴细胞）、C反应蛋白（CRP）、红细胞沉降率（ESR）、体液免疫指标（IgG、IgA）、细胞免疫指标（CD4＋T、CD8＋T）及反复肺炎病史。结果在1〉2—4岁年龄组，肥胖及超体质量儿童的平均住院时间均较正常体质量儿童长（P=0．037、0．009），肥胖儿童的总病程也较正常体质量儿童延长（P=0．014）；在≥4～7岁年龄组，肥胖及超体质量儿童的平均住院时间及总病程均较正常体质量儿童长（平均住院时间：P=0．002、0．000；总病程：P=0．004、0．001）。在／〉2～4岁年龄组，肥胖、超体质量及正常体质量儿童外周血细胞计数、CRP、ESR、IgG、IgA、CD＋T、CD8＋T、CD4＋T／CD8＋T及反复肺炎病史差异均无统计学意义（P均〉0．05）；在4～7岁年龄组，肥胖及超体质量及正常体质量儿童外周血细胞计数、ESR比较差异均无统计学意义（P均〉0．05）。但肥胖、超体质量儿童体液（IgG）及细胞免疫指标（CD4＋T、CD4＋T／CD8＋T）均较正常体质量儿童下降，肥胖儿童表现更为明显，并且肥胖及超体质量儿童更易患反复肺炎（P〈0．05）。结论i〉2—7岁肥胖及超体质量的普通肺炎儿童较正常体质量儿童需要更长的住院时间，其肺炎总病程也相对延长。免疫功能受损在≥4—7岁年龄组患儿中发挥主要作用，而在≥2～4岁年龄组中，非免疫因素可能起主要作用。
Objective To study the effect of obesity and overweight on the hospital stays and total course of common pneumonia in children and the possible reasons. Methods A total of 455 children with common pneumonia aged from 2 to 7 years were enrolled in this study ,including 147 obese children, 141 overweight children and 167 nor- real weight children. Then all the children were divided into 2 groups based on age： ≥2 -4 years group and ≥4 -7 years group. The information of the patients was collected from the medical records management system of our hospital, and including gender, age, weight, height, hospital stays, total course, peripheral blood cell counts （ white blood cell, neu- trophil, monocyte and lymphocyte ） , C-reactive protein （ CRP）, erythroeyte sedimentation rate （ESR） , IgG, IgA, CD＋ T, CD8 ＋T and the history of recurrent pneumonia. Results In ≥ 2 -4 years group, the average length of the hospital stays of common pneumonia in obese and overweight children was longer than that in the normal weight children（ P = 0. 037,0. 009） , and the total course of common pneumonia in obese children was longer than that in the normal weight children （P = 0. 014）. In ≥4 - 7 years group,the average length of the hospital stays and total course of common pneu- monia in obese and overweight children were longer than those in the normal weight children （the hospital stay：P = 0. 002,0. 000, the total course ：P = 0. 004,0. 001 ）. In t〉2 -4 years group, the peripheral blood cell counts （white blood cell, neutrophil, monocyte and lymphocyte）, CRP, ESR, IgG, IgA, CD4 ＋ T, CD8 ＋ T, CD4 ＋ T/CD8 ＋ T and the history of recurrent pneumonia were of no significant difference among obese, overweight and normal weight children （ all P 〉 0. 05 ）. In ≥4 -7 years group, the peripheral blood cell counts （white blood cell, neutrophil, monocyte and lympho- cyte） , and ESR were of no significant difference among obese, overweight and normal weight children （ all P 〉 0.05 ）
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2014年第7期506-509,共4页
Chinese Journal of Applied Clinical Pediatrics
关键词
肥胖
肺炎
住院时间
免疫功能受损
儿童
Obesity
Pneumonia
Hospital stay
Impaired immunity
Child
