摘要
目的观察注射用红花黄色素(SY)对肺心病心衰患者的心肌保护作用。方法将72例肺心病心衰患者随机分成对照组和治疗组,对照组给予常规治疗(利尿剂、血管紧张素转化酶抑制剂及平喘、止咳、化痰等对症治疗);治疗组在常规治疗的基础上,加用注射用红花黄色素100 mg静脉滴入,1次/d,总疗程10 d。观察两组患者的临床疗效、心电图、肌钙蛋白(TnI)、磷酸肌酸激酶(CK-MB)及高敏C反应蛋白(hs-CRP)的变化情况。结果治疗组总有效率(88.9%)高于对照组总有效率(66.7%)(P<0.01);治疗后,治疗组ST段压低情况与对照组比较有显著改善(P<0.01),治疗组TnI、CK-MB及CRP的下降幅度均较对照组大(P<0.05)。结论红花黄色素对肺心病心衰患者的心肌有很好的保护作用,且疗效好、不良反应少。
Objective To explore the protective effect of Safflower yellow （SY）injection on myoeardium in patients with cor pulmonale plus heart failure. Methods 72 cases with cor pulmonale plus heart failure were randomly divided into 2 groups ： control group and treatment group. The routine therapy including administration of diuretics, ACE inhibitors and symptomatic treatment for resolving phlegm, cough and asthma was performed to patients in both groups, while intravenous drip of Safflower yellow injection was added to patients in treatment group, 100 mg once a day; the total course lasted for 10 days. The curative effect and the changes of EGG,TnI,CK-MB and hs-CRP were observed. Results The total effective rate in treatment group was 88.9% ,higher than that in control group（ 66.7% ） （P 〈 0.01 ）. After treatment, the improvement of ST segment depression in treatment group was much more obvious than that in control group（ P 〈 0.01 ）, and the level of TnI, CK-MB and CRP in treatment group dropped down more than that in control group（ P 〈 0.01 ）. Conclusions Safflower yellow has a good protective effect on myocardium in patients with cor pulmonale plus heart failure, and it is of good curative effect and less side effect.
出处
《西南国防医药》
CAS
2014年第4期378-380,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
红花黄色素
肺心病
心衰
心肌
疗效
Safflower yellow
cor pulmonale
heart failure
myocardium
curative effect
