摘要
目的 分析低剂量左甲状腺素治疗先天性甲状腺功能减低症（CH）的临床疗效.方法 选择我院2009年9月至2011年11月收治的52例CH患儿作为研究对象,随机分为两组各26例.所有患儿采用药物左甲状腺素口服给药方式进行治疗.对照组患儿给予常规剂量：起始剂量为15～20μg＆#183;kg-1＆#183;d-1,维持剂量为10～20 μg＆#183;kg-1d-1;观察组患儿给予低剂量：起始剂量为5～10 μg＆#183;kg1＆#183;d-1,维持剂量为3～10 μg＆#183;kg-1＆#183;d-1.比较两组治疗60 d后的TSH、FT4水平,以及两组智能发育状况（FIQ、VIQ及PIQ）.结果 治疗60d后对照组的TSH水平高于观察组,观察组的FT4水平高于对照组,组间差异均有统计学意义（P＜0.05）;观察组的FIQ、VIQ及PIQ均高于对照组,组间差异有显著统计学意义（P均＜0.01）.结论 应用低剂量左甲状腺素对CH患儿进行治疗能够获得较好的临床疗效,可以推广应用.
Objective To analyze the clinical effect of low-dose levothyroxine for the treatment of congenital hypothyroidism （CH）. Methods Fifty-two children with CH in our hospital from September 2009 and November 2011 were selected and randomly divided into two groups, with 26 cases in each group. All cases were treated with Levothyroxine by oral administration. Patients in control group received conventional dose, with initial dose of 15 - 20μg .kg-1. d-1, and maintenance dose of 10 - 20μg .kg-1. d-1; patients in observation group received low dose, with initial dose of 5 - 10μg .kg-1. d-1, and maintenance dose of 3 - 10μg. kg-I. d-1. The TSH, FT4 level after 60 days of treatment, and the development of children＇s intelligence （FIQ, VIQ, and PIQ） were compared between two groups. Results After 60 days of treatment, the TSH level of control group was higher than that of observation group while the FT4 level of observation group was higher than that of control group （P 〈0.05）. The FIQ, VIQ and PIQ level of observation group were higher than those of control group （P 〈0.01）. Conclusions The low-dose levothyroxine can achieve good clinical effect in the treatment of children with congenital hypothyroidism and can be popularized and applied in clinic.
出处
《临床医学工程》
2014年第3期339-340,共2页
Clinical Medicine & Engineering
