摘要
大多数生物学过程都需要核因子κB(NF-κB)的参与,了解其通路过程对相关疾病的治疗有深远影响。近期发现,褪黑素作为一种吲哚类激素,自身能改变NF-κB信号通路转录过程。国内外文献表明,在消化系统、呼吸系统、心血管系统、神经系统、生殖系统等方面各类疾病的研究中,褪黑素对NF-κB蛋白质表达起抑制作用,在分子水平阻断NF-κB转录过程,下调或阻止表达产物生成,最终产生特殊的生理学效应,对从分子信号通路方面研究疾病的治疗提供了依据。
Nuclear factor K B（NF-KB） participates most of the biological processes,understanding its pathways has a far-reaching influence on related disease. Recently it＇s found that, as a kind of indoles hormone, melatonin can change the signaling pathway of NF-KB by itself. The domestic and foreign relevant literatures concluded that in the digestive system, respiratory system, cardiovascular system, nervous system, reproductive system, melatonin inhibits the protein expression of NF-KB, and blocks transcription process of NF-KB at the molecular level, downregulating or stopping the expression products, and finally results in some special physiological effects, providing a reference for the research and treatment of diseases from the perspec- tive of the molecular signaling pathways.
出处
《医学综述》
2014年第6期991-993,共3页
Medical Recapitulate
