摘要
缺血再灌注损伤(ischem ia-reperfusion in jury,IR I)是临床常见的病理过程,其发生发展过程涉及到自由基、钙超载、白细胞的呼吸爆发等损伤作用。长期以来主要围绕以上几个方面进行对IR损伤的防治。褪黑激素(m elaton in,MEL)是由松果体分泌的一种吲哚类激素,能够增强机体多个系统功能,近年来研究发现其通过抗氧化以及在分子水平发挥抗器官IR损伤作用。
Ischemia - reperfusion injury（IRI） is a common pathophysiology process in clinical, the mechanisms of which involved the damage effect of free radical, calcium overload, the respiration burst of leukocytes, and so on. Then researches of prevention and therapy for IRI are focus on the above mechanisms. There is a very applicable future for clinical applying in many resuhs of researches, and even some are having been used to alleviate IRI. Melatonin （MEL） secreted by pineal gland is is a kind of benzopyrrole hormone, which can regulate rhythm of creature and the functions of multiple systems of the bodv. In recent years, many researchers have found MEL can counteract the multiple organs IRI through its anti -oxygen effect and play a protective role in complicated molecular level.
出处
《国际病理科学与临床杂志》
CAS
2006年第4期363-366,共4页
Journal of International Pathology and Clinical Medicine
关键词
褪黑激素
缺血再灌注损伤
防治
melatonin
ischelnia-reperfusion injuly
prevention and therapy
