摘要
目的探讨马来酸桂哌齐特治疗脑梗死的临床疗效及其安全性。方法80例脑梗死患者随机分为治疗组和对照组，每组40例。2组患者入院后均给予基础治疗：控制血压、防治脑水肿、抗血小板凝集、调控血糖和血脂、预防感染。治疗组在基础治疗基础上给予马来酸桂哌齐特，320mg，加入250mL的5％葡萄糖或0．9％生理盐水中，静脉滴注，1次／d，14天为1个疗程。对照组在基础治疗基础上给予血塞通，400mg，加入250mL的5％葡萄糖或0．9％生理盐水中，静脉滴注，1次，d，14天为1个疗程。观察2组患者治疗前、治疗后的神经功能缺损程度、日常生活能力进行评分，观察临床疗效和不良反应。结果2组治疗后NDS评分均显著低于治疗前，日常生活能力评分均明显高于治疗前。治疗组治疗后NDS评分明显低于对照组治疗后，日常生活能力评分明显高于对照组治疗后。治疗组总有效率为90％，对照组总有效率为80％。2组总有效率差异无统计学意义（P〉0．05）。治疗组出现轻度头痛1例，腹痛1例，但均未影响继续治疗；对照组未出现不良反应。2组治疗过程中及治疗后监测心电图、血分析、尿组合及肝、肾功能无明显异常。结论马来酸桂哌齐特注射液治疗脑梗死临床疗效明显，无明显不良反应。
Objective To explore the clinical effect and safety of cinepazide maleate on patients with cerebral infarction. Methods A total of 80 patients with cerebral infarction were randomly divided into treatment group and control group, 40 cases for each. Basic therapies were performed to both groups after patients＇ hospitalization, such as controlling blood pressure, preventing cerebral swelling, anti-platelet aggregation, regulating blood sugar and lipid, and preventing infection, while 320 mg cinepazide maleate mixed in 250 mL 5% glucose or equivalent 0.9% normal saline were additionally performed and instilled intravenously to treatment group, and 400 mg Xuesaitong Capsule mixed in 250 mL 5% glucose or equivalent 0.9% normal saline were additionally performed and instilled intravenously to control group, qd, 14 d as a cycle. Neurological deficit severity （NDS） and activity of daily living （ADI） were scored, while clinical effect and adverse reactions were observed. Results NDS decreased whereas ADL increased significantly in both groups after treatment than treatment before, and the ranges were larger in treatment group than in control group after treatment. The total response rates in treatment group and control group were 90% and 80%, respectively, and there was no significant difference （P 〈 0.05）, whereas in the former, the main adverse reactions included 1 headache and 1 stomachache, which had no influence on continuous treatment, and in the latter, there was no adverse reaction. Additionally, there were no abnormities in electrocardiogram, haemanalysis, urine composition as well as hepatorenal functions during and after treatment. Conclusion Cinepazide maleate has favorable clinical effect and no obvious adverse reaction in treating cerebral infarction.
出处
《实用临床医药杂志》
CAS
2013年第A01期33-35,共3页
Journal of Clinical Medicine in Practice
关键词
马来酸桂哌齐特
脑梗死
临床观察
cinepazide maleate
cerebral infarction
clinical observation
