摘要
目的 :探讨 p2 7kip1在胃癌中的表达状况及其预后价值。方法 :应用免疫组化技术 (S P法 )检测了 p2 7kip1在 6 7例胃癌中的表达。结果 :p2 7kip1在胃癌中的阳性表达率为 5 0 7% ,表达呈异质性。p2 7kip1的表达与胃癌的浸润深度 (P <0 0 5 )、淋巴结转移 (P <0 0 0 5 )、分化程度 (P <0 0 5 )及临床病理分期 (P <0 0 0 5 )显著相关 ,而与肿瘤大小、部位无关。结论 :p2 7kip1在胃癌中低表达反映了其恶性进展 。
Purpose To discuss the relationship between the expression of p27 kip1 and clinicopathologic parameters and prognosis in gastric carcinoma(GC). Method Sixty seven cases of GC were studied by immunohistochemical technique. Results The positive rate of p27 kip1 expression in GC was 50 7%. Expression of p27 kip1 was heterogenous in GC. Reduced expression of p27 kip1 was significantly related to depth of tumor invasinon, lymph node metastasis, advanced stage and poor differentiation, but had no relation with the tumor size and site. Conclusion These data suggest that reduction of p27 kip1 protein may reflect the progression and high grade malignancy of GC and may be a useful indicator for prognosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
2000年第6期487-488,共2页
Chinese Journal of Clinical and Experimental Pathology
