摘要
将撞击流技术与超临界流体膨胀减压过程结合,以利福平为模型材料,考察该技术用于脂溶性药物超细微粒制备的可行性,系统分析了混合器的压力和温度、溶液浓度、进液速率、析出器的温度及撞击距离对微粒粒径及粒径分布的影响。结果表明,与超临界流体膨胀减压过程相比,超临界流体膨胀减压-撞击流技术可制备出形态更好的利福平球形微粒,微粒粒径更小、分布更均匀。采用撞击流技术后,减弱了超临界流体膨胀减压过程参数(如溶液浓度、进液速率等)对微粒的不利因素,可在较大的操作范围内制得粒径分布均匀的微粒;同时强化了液滴和热气体之间的传质和传热,微粒干燥效果得到了明显改善,在低于超临界流体膨胀减压过程适宜析出器温度10℃时,仍能得到分散性较好的微粒,有效降低了能耗。
Traditional insulation materials has the disadvantage of poor fire resistance and destructive to the en- vironment, for example, organic insulation board. In this paper, by choosing the blast furnace slag as the main raw materials and adding water glass, po[yvinyl acetate adhesive and hydrophobic agent, the non combustible blast furnace slag insulation board with low heat shrinkage and high water resistance was produced. The me- chanical properties, thermal stability, water absorbing capacity and hydrophobic of the insulation board with different additives was studied. Compression strength and water absorption of the insulation board was found to correlate with mass ratio of water glass. It was also observed that polyvinyl acetate adhesive can enhance flexur- al strength of the insulation board. The wetting angle experiment indicates that a hydrophobic film was formed on the fiber surface due to the addition of hydrophobic agent, which increases the wetting angle between the in- sulation board and water, and improves the hydrophobic nature.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2014年第4期144-148,52,152,共7页
Journal of Functional Materials
基金
河北省自然科学基金资助项目(E2012208049)
河北科技大学博士科研基金资助项目(QD200980)
