摘要
目的:研究急性心肌梗死(AMI)患者,在接受急诊经皮冠状动脉介入治疗(PCI)术前给予强化他汀治疗,对患者高敏C反应蛋白(CRP)和N末端前体脑钠肽(NT-pro-BNP)的影响。方法:收集2010-2012年急性ST段抬高型心肌梗死患者共60例,随机分为治疗组和对照组,两组在行PCI前均给予阿司匹林300mg和氯吡格雷600mg口服。治疗组在PCI前另外加用阿托伐他汀40mg。PCI术后治疗两组一样。比较两组术前,术后12h,术后24h高敏CRP和NT-pro-BNP的水平。结果:术前两组的hsCRP和NT-pro-BNP水平没有明显差异(P>0.05)。两组术后与术前相比,NT-pro-BNP水平有明显下降,治疗组指标的改善程度优于对照组。CRP在术后虽然都有所升高,但是对照组升高程度大于治疗组。差异有统计学意义(P<0.05)。结论:术前强化阿托伐他汀治疗能够降低急性心肌梗死患者NT-pro-BNP水平和控制炎症反应,改善预后。
Objective： To observe the effect of intensive statin therapy on high sensitivity C reactive protein （hsCRP） and NT-pro-BNP in patients with acute myocardial infarction （AMI） before percutaneous coronary intervention （PCI）. Methods： Sixty patients with AMI in our hospital from 2010 to 2012 were randomly divided into control group （n= 30） and intensive statin treatment group （n=30）. Both groups received aspirin 300 mg and clopidogrel 600 mg orally before PCI. The latter group also received 20 mg atorvastatin orally. The levels of hsCRP and BNP were measured before PCI, 12 hours after PCI, and 24 hours after PCI. Results： No difference was found in the levels of hsCRP and BNP between the two groups before PCI. But BNP levels of both groups after PCI were obviously decreased （P〈0.05）, and were decreased more significantly in intensive statin group. The levels of hs-CRP were increased in both groups after PCI, but the control group increased more significantly. Conclusion： Intensive statin therapy can decrease the BNP levels and improve the prognosis of patients with AMI.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2014年第2期289-291,共3页
Medical Journal of Wuhan University
