摘要
结核分枝杆菌H37Ra菌株(H37Ra)是人型结核分枝杆菌减毒株,它毒力极弱,对宿主相对安全,具备活菌疫苗的条件。与卡介苗(BCG)相比H37Ra菌株具有更完整的免疫原性,并包含一些BCG中丢失的抗原性成分。同时,H37Ra菌株能够充分活化巨噬细胞,刺激机体产生特异性免疫应答,在防治结核病中起到重要作用。因此,H37Ra菌株对机体抗结核的保护作用是否强于BCG,是否能作为抗结核的候选活疫苗已受到学者的关注,为今后研制新型、安全、高效的结核病苗奠定基础。本文对H37Ra菌株抗结核的相关研究进行了综述。
H37Ra is one type of Mycobacterium tuberculosis attenuated strain. The advantages of this strain include ex- tremely weakness in virulence, the relative safety for the host, and the requirement of living bacterium vaccine. Compared with BCG, H37Ra has more complete immunogenicity and may contain some antigenic components which BCG missed. At the same time, H37Ra strains can fully activate macrophages, stimulate the body to produce specific immune response, and play an im- portant role in the prevention and treatment of tuberculosis. Thus, protective effect of tuberculosis H37Ra on the body is stronger than BCG. Whether can as a broad prospect at the candidate of anti-tuberculosis vaccine has been attracting the atten- tion of scholars and it laid the foundation for further study of development for new, safe and efficient TB vaccine. This article is an overview concerning the H37Ra anti-tuberculosis related researches.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2014年第3期315-318,323,共5页
Chinese Journal of Zoonoses
基金
国家自然科学基金项目(No.81260261
No.81160192)
新疆生产建设兵团医药专项资金项目(No.2012BA022)~~
