摘要
目的:检测USP22在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)组织中的表达,并探讨其与OSCC的发生、发展及预后的相关性。方法:应用免疫组化染色法检测USP22在正常口腔黏膜、OSCC组织及转移淋巴结组织中的表达,并采用SPSS17.0软件对结果进行统计学分析。结果:USP22在OSCC组织中的阳性率和染色强度随组织分化程度的降低而呈增高趋势(P<0.05),USP22在转移的淋巴结组织中的表达较OSCC组织更为明显(P<0.05),OSCC病人术后5年生存率随着USP22表达的升高而降低,差异有统计学意义(P<0.05)。结论:USP22在OSCC的发生、发展及转移起到一定作用。USP22蛋白的高表达提示病人有一个差的预后。
Objective： To investigate the expression of USP22 in oral squamous cell carcinoma and to explore its correlation with the occurrence, development, and prognosis of OSCC. Methods： Immunohistoehemical staining was used to detect the expression of USP22 in normal oral mucosa, OSCC and metastatic lymph node tissues, and the experimental data were statistically analyzed through SPSS17. 0 software. Results： The expression of USP22 was upregulated with decrease of differentiation level in OSCC（P.~0.05）. The expression of USP22 was more obvi- ous in metastatic lymph node, compared with the expression of USP22 in OSCC tissue （P^O. 05）. The increased expression of USP22 was associated with low five--years survival rate in postoperative OSCC patients（P〈0.05）. Conclusion： USP22 may play a significant role in tumorigenesis, progression, and metastasis of OSCC. The patients with high expression of USP22 protein suggest a poor prognosis.
出处
《口腔医学研究》
CAS
CSCD
2014年第1期37-39,43,共4页
Journal of Oral Science Research
基金
哈医大一院院基金研究项目(编号:2012B011)
