摘要
目的通过对复方解酒灵处方进行筛选分析,确定最佳处方。方法以维生素C、还原型谷胱甘肽、牛黄酸和葛根等为处方原料,利用均匀设计法组成不同的处方配比,共设计8个处方,分别于酒前或醉酒后给小鼠灌胃,以醉酒潜伏期和醉酒时间作为考察指标,对结果进行回归分析,筛选出最优处方。结果有4个处方能明显延长小鼠的醉酒潜伏期,有7个处方能明显缩短醉酒小鼠的醉酒时间。最佳处方为维生素C72 mg/kg、还原型谷胱甘肽72 mg/kg、牛磺酸120 mg/kg、葛根1 900 mg/kg。结论由葛根、牛磺酸、还原型谷胱甘肽和维生素C等组成的复方解酒灵,具有一定的解酒作用。
Objective To determine the best combination doses of compound dealcoholization prescription by a screening analysis .Methods The uniform design was used in the experiment to design 8 prescriptions of different proportions which including vitamin C ,reduced glutathione ,Taurine and Puerarin .The medicines were administrated respectively to mice before or after drunkenness .Then the mice were observed in the latent period of drunkenness and the time of drunkenness .A regression analysis was performed to define the best proportion .Results Four prescriptions obviously prolonged the latent period of drunkenness and seven prescriptions reduced the time of drunkenness in mice . The best combination dose was vitamin C （ 72 mg/kg ） , reduced glutathione （ 72 mg/kg ） , Taurine （ 120 mg/kg ） and Puerarin（1 900 mg/kg）.Conclusion The compound dealcoholization prescription including Puerarin , Taurine, reduced glutathione and vitamin C can prevent drunkenness .
出处
《广西医学》
CAS
2014年第1期59-61,共3页
Guangxi Medical Journal
基金
广西自然科学基金资助项目(2010GXNSFA13170)
关键词
酒精中毒
复方解酒灵
中药配伍
均匀设计
解酒
Alcoholism
Compound dealcoholization prescription
Compatibility （ TCD ）
Uniform Design
Antialcoholism
