摘要
目的探讨红景天超微粉和红景天乙醇提取物对小鼠急性肝损伤的保护作用,同时比较红景天超微粉和红景天乙醇提取物在相同生药剂量下肝保护作用的差异及量效关系。方法分别以红景天超微粉物和乙醇提取物对以酒精制成急性肝损伤模型应用,测定小鼠血清中ALT,AST含量,肝脏匀浆中MDA含量,SOD的活性,同时做肝组织切片。结果红景天超微粉物和乙醇提取物明显降低因酒精所致的急性肝损伤小鼠血清中ALT,AST含量,肝匀浆中MDA含量降低和SOD的活性的升高比模型组有显著性差异(P<0.01)。结论红景天超微粉对酒精所致急性肝损伤均有保护作用,且红景天超微粉作用优于乙醇提取物。
Objective To study the protective effect of the ultra fine powder and the ethanol extract of Rhodiola sachalimernsis A. Bor, against acute liver injury in mice, and compare the protective effect and dose - effect relationship between equal dose of them. Methods The mice were perfused with ultra fine powder and ethanol extract of Rhodiola sachalimernsis A. Bor. respectively. The mouse model of acute hapatic injury was induced by ethanol and the serum levels of ALT and AST and the content of MDA, activity of SOD in liver of the mice were measured, and tissue slice of liver was made. Results The groups of ultra fine powder and ethanol extract of the Rhodiola sachalimernsis A. Bor. significantly reduced the levels of serum ALT and AST which were induced by ethanol, and the content of MDA, activity of SOD in liver were significant different compared with the model groups （P 〈 0. 01 ）. Conclusion The ultra fine powder has a protective effect against hapatic injury, and it was superior to ethanol extract.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第2期405-406,共2页
Lishizhen Medicine and Materia Medica Research
关键词
红景天超微粉
肝损伤
Ultra fine powder of Rhodiola sachalimernsis A. Bor. Liver injury
