摘要
目的探讨转化生长因子-β3(transforming growth factor-β3,TGF-β3)在臀肌挛缩症(gluteal muscle contracture,GMC)患者臀肌挛缩带中的表达及其意义。方法分别采用实时定量PCR和免疫组化检测23例臀肌挛缩症患者臀肌挛缩带和挛缩带旁臀大肌组织中TGF-β3的表达水平。结果挛缩带中TGF-β3弥漫性分布于成纤维细胞和血管内皮细胞中,呈强阳性。TGF-β3mRNA在挛缩带中的表达水平明显高于挛缩带旁臀大肌组织的表达水平,差异有统计学意义(1.76±0.63 vs1.28±0.49,P<0.05)。结论臀肌挛缩症患者臀肌挛缩带中TGF-β3表达水平升高,TGF-β3可能参与了臀肌挛缩症的发病过程。
Objective To explore the expression of transforming growth factor - β3 （TGF-β3） in patients with gluteal muscle contrac-ture （GMC） and its significance. Methods In 23 patients with gluteal muscle contracture,the expression levels of TGF-β3 were de-tected in the fibrotic muscle and adjacent muscle by real-time quantitative reverse transcription polymerase chain reaction and immuno- histochemistry. Results TGF-β3 was intensely expressed in fibroblast cells and vascular endothelial cells. The mRNA level of TGF-β3 in the fibrotic muscle was statistically higher than those in the adjacent muscle （ 1.76 ± 1. 63 vs 1.28 ± 0.49,P 〈 0. 05）. Conclu-sion The levels of TGF-β3 in the fibrotic muscle are elevated in patients with gluteal muscle contracture. TGF-β3 may participate in the occurrence of gluteal muscle contracture.
出处
《山西医科大学学报》
CAS
2013年第12期931-933,1007,共4页
Journal of Shanxi Medical University
关键词
臀肌挛缩症
转化生长因子-Β3
纤维化
gluteal muscle contracture
transforming growth factor - β3
fibrosis
