摘要
目的探讨中老年妇女骨密度和骨生化指标的变化及其意义。方法选择2010年1月至2013年6月我院门诊及住院40岁以上女性患者2446例,按年龄分成三组：①40~49岁;②50~59岁;③≥60岁,采用超声定量骨密度测定仪,按常规方法测定骨密度;采用电化学发光法测定血清I型胶原氨基端肽原（PINP）和血清β-异构C-端肽（β-CTx）;采用酶联免疫吸附法测定血清抗酒石酸酸性磷酸酶5b（TRACP-5b）和血清25羟基维生素D[25（OH）D],进行统计分析。结果骨密度值随着年龄的增长逐渐降低（P〈0.01）。PINP值随着增龄而升高（P〈0.05）,≥60岁组比40~49岁组升高更显著（P〈0.05）。β-CTx值随着增龄而升高（P〈0.01）,50~59岁和≥60岁两组比40~49岁组升高更显著（P〈0.05）。TRACP-5b在40~49岁组值最低,≥60岁组次之,50~59岁组最高（P〈0.01）,50~59岁和≥60岁两组比40~49岁组升高更显著（P〈0.05）。骨吸收指标β-CTx和TRACP-5b值较骨形成指标PINP值升高更显著。25（OH）D的结果整体偏低,均属于缺乏状态（P〈0.01）。结论中老年妇女的维生素D营养状况普遍较差,老年妇女的骨量丢失更明显,更容易发生骨折。联合检测骨密度和骨代谢生化指标,为加强中老年妇女的保健工作提供依据,对降低骨质疏松的发病率具有一定的临床意义。
Objective To investigate the change and the significance of bone mineral density and biochemical indexes of bone metabolism in middle-aged and elderly women. Methods 2446 cases of female inpatients and outpatients, aged 40 years or more had been enrolled from January 2010 to June 2013. They were divided into three groups according to age, 40 to 49years old, 50 to 59years old and ≥60years old groups. They received BMD scanning with quantitative ultrasonic bone density apparatus according to the conventional method; and serum procollagen type I - terminal propeptide （PINP） and beta- isomerized C- telopeptide （ β- CTx） were meas-ured by Roche ECLIA. The serum 25-hydroxyvitamin D （25 （OH）D） and tartaric acid phosphatase-5b （TRACP-5b） were determined by enzyme linked immunosorbent assay. Results The bone mineral density were significantly reduced with age （P 〈0.01 ）, while the serum level of PINP were increased observably with age （ P 〈 0.05 ）. The bone mineral density in group less than 60 years old increased more obviously than group 40 to 49 years old（P 〈0.05）. The serum level 15-CTx were increased observably with age （P 〈0.01 ）, The serum level 15- CTx in group of 50 to 59 years old and over 60 years old increased more significantly than group of 40 to 49 years old （P 〈0.05）. The TRACP-5b values in the group less than 40 to 49 years old were mini- mum, the group aged more than 60 came second, and the group aged 50 to 59 showed maximum. The bone re- sorption beta CTx and TRACP-5b value increased more obviously than bone formation PINP value. The serum concentrations of 25-hydroxyvitamin D showed low values as a whole, all in the lack of state （P 〈 0.01 ）. Conclusion Middle-aged and old women vitamin D nutritional status is generally poor. Elderly women＇s bone mass loss is more obvious, and bone fracture occurs more obvious. Combined detection of bone mineral density and bone metabolism biochemical indexes, which provide the basis to strengthen the health
出处
《标记免疫分析与临床》
CAS
2013年第6期417-421,共5页
Labeled Immunoassays and Clinical Medicine
关键词
中老年妇女
骨密度
骨代谢生化指标
Middle-aged and elderly women
Bone mineral density
Biochemical indexes of bone metabolism
