摘要
目的探讨绝经后妇女骨代谢标志物与骨质疏松的相关性。方法应用双能X线骨密度仪测量绝经期妇女腰椎和股骨的骨密度值,并按骨密度值将136例患者分为63例骨量减少组和73例骨质疏松组,用电化学发光法测定两组患者血清骨钙素(N-MID),总骨I型前胶原N端肽(PINP)和β胶原特殊序列(β-crosslaps)的水平。结果在骨量减少组和骨质疏松组血清N-MID测定结果分别为21.63±24.77ng/mL和21.4±15.6ng/mL、PINP分别为46.8±46.37ng/mL和61.4±52.83ng/mL、β-crosslaps分别为0.48±0.46ng/mL和0.49±0.40ng/mL,两组间的差异无统计学意义(P>0.05)。结论绝经后骨质疏松患者血清骨代谢标志物水平与骨密度不存在密切的相关性;血清N-MD、PINP、β-Crosslaps只反映绝经后妇女骨转换的高低,对骨质疏松的诊断无明显帮助。
Objective To explore the correlation between bone turnover markers and osteoporosis in postmenopa- usal women. Methods BMD value of the lumbar and femur was measured by dual-energy X-ray absorption me- ter. The 136 patients were divided into osteopenia group （63 cases） and osteoporosis group （73 cases） accord- ing to the BMD level. The serum bone turnover markers osteocalcin （ N- MID） , N- terminal propepfide of type I proeollagen （PINP） and β collagen specific sequences （β-crosslaps） were detected by electrochemical lumi- nescence method. Results There was no significant difference for serum N-MID, PINP, β-Crosslaps between osteopenia group and osteoporosis group （ P 〉 0.05 ）. Conclusion No significant correlation has been found be- tween the levels of serum markers of bone turnover and BMD in patients with postmenopausal osteoporosis. The serum N- MID, PINP and β- crosslaps sould only reflect the level of bone remodeling in postmenopausal women while having limited value for diagnosis of osteoporosis.
出处
《标记免疫分析与临床》
CAS
2012年第6期351-353,共3页
Labeled Immunoassays and Clinical Medicine
