摘要
目的探讨玻璃酸钠关节腔内注射治疗膝骨性关节炎(OA)的疗效及护理体会。方法选择2011年8月～2012年8月义乌市中医医院72例膝关节OA患者,采用随机数字表将纳入患者分为观察组(n=36)和对照组(n=36)。对照组和观察组分别予以泼尼松龙注射液50 mg、玻璃酸钠注射液20 mg关节腔内注射,每周1次,连用4周。观察并比较两组患者治疗4周后的近期疗效及药物不良反应,并记录随访6个月后的远期疗效。结果治疗4周后,观察组的近期临床总有效率(94.44%)明显高于对照组(72.22%)(χ2=6.40,P<0.05)。两组患者治疗过程中药物不良反应发生率(11.11%比5.56%)比较差异无统计学意义(χ2=0.18,P>0.05)。治疗后随访6个月,观察组远期临床总有效率(86.11%)明显高于对照组(55.56%)(χ2=8.13,P<0.01)。结论玻璃酸钠关节腔内注射膝关节OA近期及远期效果均良好,安全性较好。而做好注射期间护理是提高临床效果、减少药物不良反应的关键。
Objective To discuss curative effect observation and nursing experience of osteoarthritis （OA） medical treatment by intra-articular injection of Sodium Hyaluronate.Methods 72 cases of OA patients from August 2011 to August 2012 collected by Yiwu Traditional Chinese Medical Hospital were divided into observation group and control group at random by table of random number.Prednisolone （50 mg） or Sodium Hyaluronate （20 mg） was given to the patients in control group or observation group by intra-articular injection,once a week,for 4 weeks continuously.After 4 weeks＇ medical treatment,the recent curative effect and drug adverse reaction of patients in two groups were observed and compared,and the long-term effects were recorded for 6 months later.Results After 4 weeks＇medical treatment,the recent total clinical effective rate in observation group （94.44％） was much higher than that in control group （72.22％） （x2 =6.04,P ＜ 0.05）.After comparing the incidence rates of drug adverse reaction of patients in two groups （11.11％ vs 5.56％）,the result had no obvious statistical difference （x2=0.18,P ＞ 0.05）.After 6 month＇medical treatment and follow-up,the long-term total clinical effective rate in observation group （86.11％） was much higher than that in control group （55.56％） （x2 =8.13,P ＜ 0.01）.Conclusion Intra-articular injection of Sodium Hyaluronate has both benign recent and long-term effect on OA patients,which may sign with good security,and has positive effect on OA in both medical treatment and prevention of recurrence.Moreover,good nursing during the injection is the key point of improvement of clinic effect and reduction of drug adverse reaction.
出处
《中国医药导报》
CAS
2013年第25期134-136,共3页
China Medical Herald
基金
浙江省医学会临床科研基金项目(编号Y2011ZYC-B64)
关键词
膝骨性关节炎
玻璃酸钠
泼尼松龙
关节腔内注射
Knee osteoarthritis
Sodium Hyaluronate
Prednisolone
Intra-articular injection
