摘要
目的:对比研究急诊肝动脉化疗栓塞术(TACE)与肝动脉栓塞术(TAE)治疗原发性肝癌破裂出血的短期和长期治疗效果。方法:回顾性分析从2002年3月至2012年12月原发性肝癌自发性破裂出血45例患者临床资料,对比研究急诊TACE与TAE两种治疗方法在短期止血效果、无进展生存期(PFS)和中长期生活质量的差异。结果:两组病例介入手术均操作成功,达到止血效果。随访研究发现,与TAE治疗组相比,TACE治疗组患者术后肿瘤明显缩小,患者无进展生存率和生活质量均有显著提高。结论:急诊介入栓塞化疗是原发性肝癌自发性破裂出血的首选治疗方法。与TAE相比,TACE既能达到同样的止血效果,还能显著提高术后无进展生存率和生活质量,尤其适用于早、中期BCLC肝癌自发性破裂出血患者。
Objective:To compare the short-term and long-term effects of emergency TACE and TAE treatment for spontaneous rupture and bleeding of primary liver cancer.Methods:45patients with spontaneous rupture and bleeding of primary liver cancer were retrospectively analyzed,dating from March 2002to December 2012.The differences were comparatively studied between TACE and TAE in emergency hemostatic effects,progression-free survival(PFS)and long-term life quality.Results:The patients of both groups all obtained successful hemostasis.The follow-up study found that,compared with TAE treatment group,the tumor size of TACE treatment group was significantly less,and the progression-free survival(PFS)and long-term life quality were significantly improved.Conclusion:Emergency TACE is the preferred treatment for spontaneous rupture and bleeding of primary liver cancer.Compared with TAE,TACE can achieve the same hemostatic effect,while significantly improving post-operative progression-free survival and quality of life.TACE is especially suitable for the early and middle stage BCLC patients with spontaneous rupture and bleeding.
