摘要
目的分析江西省南昌市2012年临床诊断为手足口病患者标本的病原学检测结果,为手足口病的临床诊治和防控提供实验室依据。方法采用实时荧光定量反转录-聚合酶链反应(real time RT-PCR)对2012年1—12月间1028例医院诊断为手足口病的患者标本核酸进行鉴定分型,并统计分析。结果临床诊断为手足口病的患者标本1028份中,632份为肠道病毒通用阳性,总阳性率为61.48%,其中肠道病毒71型(EV71)、柯萨奇病毒A组16型(Cox A16)、EV71和Cox A16混合感染、其他肠道病毒阳性检出率分别为39.0%、10.21%、0.09%和12.16%。病原学检测阳性标本中男女性别比为1.8∶1;发病年龄段主要集中在5岁以下儿童(94.36%),尤其是3岁以下男童。结论 2012年南昌地区手足口病的主要病原体为EV71,且较2009—2011年有上升趋势。
Objective To understand the etiological characteristics of hand foot and mouth disease （HFMD） in Nanchang in 2012 and provide scientific evidence for the prevention and control of HFMD. Methods From January to December 2012, a total of 1028 samples were collected from clinically diagnosed HFMD cases for detection of entericvirus with real time RT-PCR. Results Entericviruses were detected in 632 of 1028 samples （61.48%）, and 401 were positive for EV71 （39. 0% ）, 105 were positive for Cox A16 （ 10. 21% ） ; 1 was identified as co-infection with EV71 and Cox A16; 125 were positive for other unknown entericviruses （12. 16% ）. The male to female ratio of laboratory confirmed patients was 1.8： 1. HFMD mainly occurred in children aged 〈 5 years （94. 36% ）, especially in boys less than 3 years old. Conclusion The major pathogen causing HFMD was EVT1 in Nanchang in 2012, and its proportion increased compared with 2009 -2011.
出处
《疾病监测》
CAS
2013年第11期905-907,共3页
Disease Surveillance
关键词
手足口病
EV71
COX
A16
流行特征
病原学监测
hand foot and mouth disease
entericvirus 71
coxsackievirus A16
epiderniological characteristic
etiological surveillance
