摘要
目的探讨高功率密度毫米波远位照射和联合放疗的抗瘤效应及可能机制。方法小鼠肝癌种瘤模型分组，观察动物生存期、瘤重及有丝分裂细胞数。 Ａ组为种瘤对照组；Ｂ组为单纯放疗组，全肝 γ－射线照射 ２ Ｇｙ ×６次；Ｃ组为单纯毫米波组，动物背部照射毫米波 ３０分钟× １４次；Ｄ组为综合组，先照射毫米波后 γ－射线放射，剂量同Ｂ组和Ｃ组。结果各组平均生存日分别为１９、２５．８、３１．３和３３．３天（Ｐ＜０．０１）；平均瘤重分别为１，０９、０．５９、０． ２５、０． ２０ ｇ（Ｐ＜０． ０１）；每视野核分裂细胞数分别为 ３２． ２、２２． ６、１６． ２、１５． ４只（Ｐ＜０．０１）。联合组小鼠生存延长率达７５．３％、抑瘤率８１．２％、核分裂抑制率５２．２％。结论高功率密度毫米波对实验小鼠具有良好的远位抗瘤效应，联合放疗效果最好，从而提示两者的协同抗瘤增敏效应。
Objective To observe antitumor effect of high power density(HPD) millimeter wave radiation of distance from tumor and γ-ray irradiation on animal survival,tumor wieght and cell mitosis. Methods The embedding hepatoma model of mouse was used. Group A had no treatment. Group B received γ-ray irradiation to liver area with 2 Gy by 6 times. Group C received HPD millimeter wave radiation from distance of tumor for 30 minutes by 14 times. Group D received γ-ray and HPD millimeter wave combinedly. Results The mean survival at group A .B .C and D was 19、 25. 8、 31. 3 and 33. 3 days, respectively (P<0. 01 ). The mean tumor weight at group A.B.C and D was 1. 09、 0. 59、 0. 25 and 0. 20 g, respectively (P<0. of ). The numbers of mitotic cells of microscopic field at group A 、B、C and D were 32. 2、 22. 6、 16. 2 and 15. 4,respectively(p<0. o1 ). Compared with control group (group A), the survival time of combined therapy group (group D) increased by 75. 3%, tumor weight decreased by 81. 2% and the mitosis inhibition rate was 52. 2%. Conclusion HPD millimeter wave radiation has a good antitumor effect. It is proved that HPD millimeter wave radiation combined with γ-ray irradiation has a synergistic anti tumor effect.
出处
《实用肿瘤杂志》
CAS
北大核心
2000年第6期371-373,共3页
Journal of Practical Oncology
基金
上海市科技发展基金资助项目!(No.98ZB14031)
关键词
肝肿瘤
放射疗法
小鼠
毫米波远位照射
microwares/therapeutic use
liver neoplasma, experimental/radiotherapy
liver neoplasma, experimental/ therapy
γ-ray
mice
