摘要
目的比较阿立哌唑和利培酮治疗精神分裂症抑郁症状的疗效。方法将56例伴有抑郁症状的精神分裂症患有随机分为利培酮组(对照组)和阿立哌唑组(研究组)治疗,观察时间为8周。采用卡尔加里精神分裂症抑郁量表(CDSS)、阳性和阴性症状量表(PANSS)评定疗效,采用不良反应量表(TESS)评定不良反应。结果治疗8周后两组抑郁症状有效率比较差异有统计学意义(χ2=11.2,P<0.01);两组CDSS减分率差异有统计学意义(t=13.65,P<0.01),两组不良反应发生率无差异无统计学意义(P>0.05)。结论阿立哌唑改善精神分裂症抑郁症状明显优于利培酮。
Objective To compare the efficacy between Aripiprazole and Risperidone in the treatment of schizophrenia with depression. Methods 56 patients suffering from schizophrenia with depression were randomly divided into Aripiprazole group （control group） and Risperidone group （study group）. All of the eases were treated with Aripiprazole or Risperidone for 8 weeks. The effieacy and side effects were evaluated with CDSS, PANSS and TESS. Results After the treatment of 8 weeks, there was statistically significant difference in effective rate of depression between the two groups（x 2=11.2, P〈 0.01）; The difference in CDSS reducing score rate between the two groups was statistically significant（t=13.65, P〈 0.01）; The difference in the incidence of adverse reactions between the groups was not statistical significant （P 〈 0.05）. Conclusion The effieaey of Aripiprazole is superior to Risperidone in the treatment of schizophrenia with depression.
出处
《中外医疗》
2013年第29期42-43,共2页
China & Foreign Medical Treatment
