摘要
目的探讨两种不同方案治疗艾滋病合并细菌性肺炎患者的有效性及安全性。方法采用回顾性研究方法，观察两种不同方案对艾滋病合并细菌性肺炎患者的治疗效果，A组（98例）给予注射用哌拉西林钠他唑巴坦钠2．25g加入0．9％氯化钠注射液100mL静滴，1次／6h；B组（86例）给予盐酸莫西沙星0．4g加入0．9％氯化钠注射液250mL静滴，1次／d。两组均连用10～14d。结果两种药物治疗方案有效率分别为91．84％，81．40％（P〈0．05），细菌清除率分别为86．2％，70．0％（P〈0．05），药物不良反应发生率分别为22．4％，18．6％（P〉0．05），但发生药物不良反应病例中，出现肝、肾损伤比率为59．1％，28．57％（P〈0．05）。结论综合考虑哌拉西林钠他唑巴坦钠是治疗艾滋病合并细菌性肺炎较好的选择。
Objective To evaluate the effectiveness and safety of different antimicrobial solution for bacteria pneumonia patients with AIDS. Method The curative effect of different antimicrobial solution for bacteria pneumonia patients with AIDS was retrospectively analyzed. Patients in group A （98 cases） were treated with 2.25 g Piperacillin sodium and tazobactam sodium which was added in 100mL 0.9% sodium chloride, four times a day, while patients in group B （86 cases） with 0. 4g Moxifloxacin Hydrochlofide which was added in 250mL 0.9% sodium chloride,once a day. The treatment lasted for 10 to 14 days. Results In two groups, the effectiveness rate were 91.8% and 81.4% respectively （P 〈 0.05 ） and the bacterial eradication rate were 86.2% and 70.0% respectively （ P 〈 0. 05 ）. The incidence rate of adverse drug reactions in two groups were 22. 4% and 18.6% respectively（P 〉 0. 05 ）, and liver damage and kidney damage account for 59. 1% and 28.6% of the cases （ P 〈 0.05 ）. Conclusion In a whole, piperacillin sodium and tazobactam sodium is the best solution for bacterial pneumonia patients with AIDS.
出处
《内科》
2013年第5期463-465,共3页
Internal Medicine
基金
广西壮族自治区卫生厅医药计划科研项目(Z2009016)
