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WNT信号通路及其与唇腭裂发生 被引量：3

WNT signal and its relation with cleft lip and palate
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摘要 WNT信号通路作为调控胚胎发生的四大信号转导途径之一,主要参与细胞的增殖、分化和极化以及程序性细胞死亡和抗程序性细胞死亡等,近年来其研究逐渐成为热点。唇腭裂作为最常见的先天性畸形,其发病机制至今尚无定论。研究显示,WNT信号通路与唇腭裂发生关系密切,本文就WNT信号通路及其与唇腭裂发生的研究进展作一综述。 WNT signal is involved in embryonic development. It is mainly involved in cell proliferation, differentiation, polarization, apoptosis, and anti-apoptosis. Recently, it has become the focus of many research. Cleft lip and palate are the major congenital malformations, and their pathogenesis is unclear. The WNT signal has been shown to have a close relationship with cleft lip and palate. This review summarized the research progress of WNT signal and its relation with cleft lip and palate.
作者 蔡生青 王 石冰
机构地区 口腔疾病研究国家重点实验室华西口腔医院唇腭裂外科(四川大学)
出处 《国际口腔医学杂志》 CAS 2013年第6期786-789,共4页 International Journal of Stomatology
基金 国家自然科学基金资助项目(81100740)
关键词 WNT信号通路 信号转导 唇裂 腭裂 发生 WNT signaling signal transduction cleft lip cleft palate happen
分类号 R782.2 [医药卫生—口腔医学]
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参考文献21

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二级参考文献12

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共引文献4

同被引文献41

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引证文献3

二级引证文献11

国际口腔医学杂志
2013年 第6期

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