摘要
心脏电压门控钠通道是位于心肌细胞膜表面的跨膜糖蛋白,主要参与心肌动作电位0期除极和传导,是维持心肌细胞正常兴奋性和传导性的重要离子通道。
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2013年第11期874-877,共4页
Chinese Journal of Pediatrics
基金
国家自然科学基金资助项目(30371571)
参考文献31
-
1Rook MB,Evers MM,Vos MA,et al.Biology of cardiac sodiumchannel Navi.5 expression.Cardiovasc Res,2012,93:12-23. 被引量:1
-
2Shy D,Gillet L,Abriel H.Cardiac sodium channel NaVl.5distribution in myocytes via interacting proteins:the multiple poolmodel.Biochim Biophys Acta,2013,1833:886-894. 被引量:1
-
3BIOBASE.Human gene mutationdatabase[EB/OL].[2013-05-13].http://www.biobase-intemational.com/product/hgmd. 被引量:1
-
4Song W,Shou W.Cardiac sodium channel Navi.5 mutations andcardiac arrhythmia.Pediatr Cardiol,2012,33:943-949. 被引量:1
-
5Tfelt-Hansen J,Winkel BG,Grunnet M,et al.Inherited cardiacdiseases caused by mutations in the Navi.5 sodium channel.JCardiovasc Electrophysiol,2010,21:107-115. 被引量:1
-
6Abriel H,Kass RS.Regulation of the voltage-gated cardiac sodiumchannel Navi.5 by interacting proteins.Trends Cardiovasc Med,2005,15:3540. 被引量:1
-
7Abriel H.Cardiac sodium channel Na(v)1.5 and interactingproteins:Physiology and pathophysiology.J Mol Cell Cardiol,2010,48:2-11. 被引量:1
-
8Remme CA,Bezzina CR.Sodium channel(dys)function andcardiac arrhythmias.Cardiovasc Ther,2010,28:287-294. 被引量:1
-
9Zimmer T,Surber R.SCN5A channelopathies-an update onmutations and mechanisms.Prog Biophys Mol Biol,2008,98:120-136. 被引量:1
-
10Beme P,Brugada J.Brugada syndrome 2012.Circ J,2012,76:1563-1571. 被引量:1
二级参考文献19
-
1雷鸣,Goddard C,孙思,Colledge W H,Grace A A,Huang C L.SCN5A-△KPQ变异的长QT综合征的细胞电生理[J].临床心血管病杂志,2005,21(4):195-197. 被引量:1
-
2Rodriguez-Calvo MS, Brion M, Allegue C, et al. Molecular genetics of sudden cardiac death. Forensic Sci Int,2008,182 : 1 - 12. 被引量:1
-
3Fatkin D, MacRae C, Sasaki T, et al. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated eardiomyopathy and conduction-system disease. N Engl J Med, 1999, 341 : 1715-1724. 被引量:1
-
4Syrris P, Murray A, Carter ND, et al. Mutation detection in long QT syndrome: a comprehensive set of primers and PCR conditions. J Med Genet,2001,38 :705-710. 被引量:1
-
5Goldenberg I, Zareba W, Moss AJ. Long QT Syndrome. Curr Probl Cardiol,2008, 33:629-694. 被引量:1
-
6Itoh T, Tanka T, Ryozo N, et al. Genomic organization and mutational analysis of KCNH2, a gene responsible for familial long QT syndrome. Hum Genet, 1998,102 : 435-439. 被引量:1
-
7Zareba W, Cygankiewicz I. Long QT Syndrome and Short QT Syndrome. Prog Cardiovasc Dis,2008,51:264-278. 被引量:1
-
8Morita H, Wu J, Zipes DP. The QT syndromes: long and short. Lancet ,2008,372 : 750-763. 被引量:1
-
9Splawski I, Shen J, Timothy KW, et al. Spectrum of mutations in long-QT syndrome genes: KVLQT1, HERG, SCNSA, KCNE1, and KCNE2. Circulation, 2000,102 : 1178-1185. 被引量:1
-
10Zimmer T, Surber R. SCNSA channelopathies: An update on mutations and mechanisms. Prog Biophys Mol Biol, 2008,5 : 1- 17. 被引量:1
同被引文献63
-
1Muhammad Tariq,Stephanie M Ware.Importance of genetic evaluation and testing in pediatric cardiomyopathy[J].World Journal of Cardiology,2014,6(11):1156-1165. 被引量:6
-
2周士胜.氯通道:在心脏中起何作用?[J].生理学报,2006,58(2):104-109. 被引量:4
-
3方丹红,吴立群,陆林,楼盛,顾刚,沈永初,陈秋静,蒲里津,沈卫峰.心脏钠离子通道α亚单位SCN5A基因多态性与特发性室性心律失常[J].诊断学理论与实践,2007,6(4):353-357. 被引量:3
-
4姚金朋,高尔.心脏氯离子通道研究进展[J].医学综述,2007,13(22):1688-1691. 被引量:4
-
5Charles Antzelevitch,Pedro Brugada,Martin Borggrefe,Josep Brugada,Ramon Brugada,Domenico Corrado,Ihor Gussak,Herve LeMarec,Koonlawee Nademanee,Andres Ricardo Perez Riera,Wataru Shimizu,Eric Schulze-Bahr,Hanno Tan,Arthur Wilde.Brugada Syndrome: Report of the Second Consensus Conference: Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association[J]. Circulation . 2005 (5) 被引量:2
-
6Song WH. Shou WN. Cardiac Sodium Channel Nav 1. 5 Mutations and Cardiac Arrhythmia[J]. Pediatric Cardiolo gy,2012,33(6) :943-949. 被引量:1
-
7Wang Q,Shen J, Li Z,et al. Cardiac Sodium Channel mu- tations in patients with long QT syndrome, an inherited cardiac arrhythmia[J]. Hum Mol Genet, 1995,4 (9): 1603 -1607. 被引量:1
-
8Jiang C,Atkinson D,Towbin JA,et al. Two long QT syn- drome loci map to chromosomes 3 and 7 with evidence for further heterogeneity[J]. Nat Genet, 1994,8(2):141- 147. 被引量:1
-
9Vincent GM, Timothy KW, Leppert M, et al. The spec- trum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome[J]. New Engl J Med, 1992,327(12) :846-852. 被引量:1
-
10Antzelevitch C. In vivo human demonstration of phase 2 reentry[J]. Heart rhythm,2005,2(8) :804 -806. 被引量:1
引证文献4
-
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-
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-
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-
4刘瑶,张海澄.家族性病态窦房结综合征的钠通道异常[J].中华心脏与心律电子杂志,2015,3(2):58-61. 被引量:1
二级引证文献5
-
1林玥,丁涛,陈革,王鑫,温富春,纪凤兰,刘博,徐惠波.苦参总碱对乌头碱诱发心肌细胞凋亡的保护作用[J].中药药理与临床,2021,37(6):32-37. 被引量:5
-
2陈玉先.探讨不同阶段年龄对阿托品试验结果的影响[J].智慧健康,2018,4(20):79-80.
-
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-
4李志伟,叶圣权,高峰,孟强,张珊珊,赵丽军,丁建,王祖禄.不同剂量重组人脑利钠肽治疗老年难治性心力衰竭并室性心律失常的效果[J].国际老年医学杂志,2022,43(4):410-414. 被引量:7
-
5庞舜予,张雅琪,罗佳欣,唐敏利,李清伶,陈颖卿,刘丽萍.中药单体抑制心律失常的离子通道机制研究进展[J].中草药,2022,53(15):4853-4861. 被引量:10
-
1薛冠华,王正义,廖德志,潘敬运,詹澄扬.不同浓度吗啡对心肌动作电位的作用及其机制[J].生理学报,1990,42(4):323-330. 被引量:8
-
2李务荣,王朝霞,张巍,吕鹤,徐洪亮,洪道俊,姚生,袁云.骨骼肌钠离子通道病17例患者的临床病理和基因分析[J].中华神经科杂志,2014,47(1):7-11. 被引量:7
-
3王沛,雪原.骨组织工程研究中整合素的意义[J].中华骨科杂志,2006,26(9):633-636. 被引量:1
-
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-
5刘承云,耿小晶,陈桂青,郭唐猛,万晶晶,戚本玲.花生四烯酸对兔心室肌细胞电压门控钠通道的影响[J].中国药理学通报,2009,25(3):331-335.
-
6施琦,张鸿德,徐有秋.α_1-肾上腺素受体激动对心肌动作电位的影响[J].上海第二医科大学学报,1989,9(3):213-220.
-
7岳晓兰,曾晓荣,杨艳.BK_(Ca)β_1亚单位调控机制研究及其与离子通道病的关系[J].四川生理科学杂志,2008,30(3):123-125. 被引量:2
-
8叶序卷,王立.树突状细胞与相关激素的基础研究[J].中国免疫学杂志,2005,21(12):957-959.
-
9柏宏伟,李向红,宋欣,侯宁.大鼠脑缺血再灌注后微血管通透性变化[J].微循环学杂志,2001,11(4):3-4. 被引量:1
-
10刘智良,徐如祥,张英鸽,张飒,蒋霞,张德添,杨怡,姜晓丹,邹雨汐,杜谋选.红藻氨酸作用后海马神经元胞膜表面的超微结构的原子力显微镜观察[J].第一军医大学学报,2003,23(7):659-662. 被引量:3