摘要
药用植物中存在许多具有显著药理活性的天然单体成分,在抑制心律失常方面具有独特的优势。近年来,诸多学者从不同的角度开展了大量中药单体成分缓解心律失常的基础研究。经过深入总结其作用机制,发现中药单体成分抑制心律失常主要集中在抑制钾离子、钠离子、钙离子通道等方面。综述了中药单体抑制心律失常的离子通道机制研究进展,旨在为调节心律失常中药单体的基础研究提供思路,同时为基于中药活性成分的创新药物研发提供理论依据。
There are many natural monomers with significant pharmacological activities in medicinal plants, which have unique advantages in inhibiting arrhythmia. In recent years, many scholars have carried out a large number of basic studies on antiarrhythmic effects of traditional Chinese medicine monomers from different angles. After deeply summarizing its mechanism, it was found that the inhibition of arrhythmia by traditional Chinese medicine monomers mainly focuses on inhibition of potassium ion, sodium ion, calcium ion channel.Research progress on ion channel mechanism of traditional Chinese medicine monomers inhibiting arrhythmia is reviewed in this paper,in order to provide ideas for basic research of traditional Chinese medicine monomers for regulating arrhythmia, and provide a theoretical basis for research and development of innovative drugs based on active components of traditional Chinese medicine.
作者
庞舜予
张雅琪
罗佳欣
唐敏利
李清伶
陈颖卿
刘丽萍
PANG Shun-yu;ZHANG Ya-qi;LUO Jia-xin;TANG Min-li;LI Qing-ling;CHEN Ying-qing;LIU Li-ping(Dalian Key Laboratory of Chronic Disease Research Center,Dalian University,Dalian 116622,China;Liaoning Key Laboratory of Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products,Dalian University,Dalian 116622,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第15期4853-4861,共9页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金面上项目(82000074)
辽宁省教育厅科学研究经费项目(jyt-dldxjc202005)
大连市青年科技之星基金项目(2020RQ080)
大学生创新创业训练计划项目(S202111258034)。
关键词
中药单体
心律失常
离子通道机制
钾离子
钠离子
钙离子
葛根素
阿魏酸
青蒿素
甘草次酸
人参皂苷RE
白花前胡甲素
丹皮酚
traditional Chinese medicine monomer
arrhythmia
ion channel mechanism
potassium ion
sodium ion
calcium ion
puerarin
ferulic acid
artemisinin
glycyrrhetinic acid
ginsenoside Re
praeruptorin A
paeonol
