摘要
目的应用Meta分析方法探讨幽门螺旋杆菌(Hp)感染相关十二指肠溃疡(DU)三联药物治疗后是否有必要继续接受质子泵抑制剂(PPI)抗酸治疗。方法在MEDLINE、Cochrane等数据库检索国内外已公开发表的关于Hp感染相关DU三联药物治疗和三联药物治疗后继续接受PPI抗酸治疗方案的随机对照研究文献,按Meta分析要求处理有关数据、分析评价。结果共有5篇文献入选,结果显示:治疗后DU愈合率总样本数为1 657,其中治疗组为829,对照组为828,P=0.35,差异无统计学意义,优势比OR=1.14,95%CI[0.86,1.51];治疗后Hp根除率总样本数为1 209,其中治疗组为604,对照组为605,P=0.23,差异无统计学意义,优势比OR=1.19,95%CI[0.89,1.59]。结论三联药物治疗后再接受奥美拉唑抗酸治疗能提高Hp感染相关DU的治愈率,但优势不明显。因此,在治疗Hp感染相关DU时接受了三联疗法后,不需再接受PPI抗酸治疗。
Objective To investigate whether the PPI acid treatment for Hp-related DU was necessary to continue after triple therapy by Meta analysis.Methods MEDLINE,Cochrane were searched for randomized controlled trials（RCTs） that reported the effects of triple therapy for Hp-related DU and the PPI acid treatment for Hp-related DU after triple therapy published at home and abroad.Meta-analysis software was used to analyze and evaluate the data.Results A total of 5 RCTs were included.1 657 in the sample of DU healing rate after treatment,of which the treatment group was 829,the control group was 828,P=0.35,OR=1.14,95% CI[0.86,1.51]; 1 209 in the sample of Hp eradication rate,of which the treatment group was 604,the control group was 605,P=0.23,OR=1.19,95% CI[0.89,1.59].Conclusion It can increase the healing rate of Hp-related DU to some extent which received the omeprazole acid treatment after triple therapy,but the advantage is not obvious.Therefore,it is no need to continue the PPI acid treatment for it.
出处
《实用药物与临床》
CAS
2013年第9期814-817,共4页
Practical Pharmacy and Clinical Remedies
