摘要
目的：研究兰索拉唑三联疗法治疗幽门螺杆菌（Ｈｐ）相关性十二指肠溃疡疗效及安全性，比较１周疗法与２周疗法的Ｈｐ根除率、溃疡愈合率及疼痛缓解率。方法：４６例经胃镜证实的Ｈｐ阳性的十二指肠溃疡患者，随机分成１周疗法组（Ａ组）和２周疗法组（Ｂ组），Ａ组、Ｂ两组用药均为兰索拉唑３０ｍｇ，ｂｉｄ；阿莫西林１．０ｇ，ｂｉｄ；甲硝唑０．４ｇ，ｂｉｄ。Ａ组抗生素（阿莫西林和甲硝唑）只用１周，Ｂ组用２周，兰索拉唑均用２周。停药４周之后复查胃镜观察溃疡愈合、Ｈｐ根除及疼痛缓解情况。结果：溃疡愈合率Ａ组Ｂ两组分别为８５．７％（１８／２１）和９２．０％（２３／２５）；Ｈｐ根除率为７１．４％（１５／２１）和８４％（２１／２５）；３ｄ和７ｄ之内的疼痛缓解率Ａ组分别为７０．６％（１２／１７）和９４．１％（１６／１７）；Ｂ组分别为７１．４％（１５／２１）和９０．５％（１９／２１）；平均疼痛缓解日数Ａ组（３．３±２．４）ｄ；Ｂ组（３．５±２．８）ｄ。Ａ，Ｂ两组之间比较，各项结果均无明显差异（Ｐ＞０．０５）。
OBJECTIVE: To compare the 1 week and 2 weeks H.pylori eradication rate,ulcer healing rate,pain relief rate,and safety of lansoprazole triple therapy in treatment of patients with H.pylori infection associated with duodenal ulcer.METHODS:46 patients with positive H.pylori and active duodenal ulcer were randomly divided to receive 1 week or 2 weeks treatment with lansoprazole triple regimen(composed of amoxicillin in a daily dose of 1 g,metronidazole in a dose of 0.4 g twice daily and lansoprazole in a dose of 30 mg twice daily).RESULTS:Ulcer healing rate:85.7% for 1 week group and 92% for 2 weeks group; H.pylori eradication rate:71.4% for 1 week group and 84% for 2 weeks group;pain relief rate:70.6% and 94.1% for day 3 and 7 in l week group,and 71.4% and 90.5% for the corresponding values in the 2 weeks group.CONCLUSION:No significant difference existed between the two groups in H.pylori eradication rate,effective rate and safety.
出处
《中国新药杂志》
CAS
CSCD
1999年第4期246-248,共3页
Chinese Journal of New Drugs
