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舒芬太尼与吗啡硬膜外自控镇痛效果及对胃肠功能影响的比较 被引量:2

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摘要 目的比较吗啡、舒芬太尼用于病人术后硬膜外自控镇痛(PCEA)的镇痛效果及对胃肠功能影响。方法60例拟在腰_硬联合麻醉下行妇科手术的患者,AsAI一Ⅱ级,随机分为A、B两组,每30例。A组镇痛药配方为吗啡5mg+氟哌利多2.5mg+1%罗哌卡因15mL+0.9%生理盐水共计100mLIB组舒芬太尼50斗g代替A组配方中的吗啡。设置负荷剂量为5mL,背景剂量为1h3mL,自控药量1次2mL,锁定时间15min。观察病人术后24h镇痛效果,记录镇痛泵使用情况、不良反应以及肠鸣音、肠蠕动恢复时间。结果吗啡组在术后24h的镇痛效果优于舒芬太尼组(P〈0.05)。吗啡组头晕、恶心呕吐、皮肤瘙痒等发生率高(P〈0.05)。舒芬太尼组肠鸣音、肠蠕动恢复时间明显短于吗啡组。结论舒芬太尼复合低浓度罗哌卡因可安全有效地用于腹部手术PCEA,镇痛效果弱于吗啡,但不良反应少,肠蠕动恢复时间明显缩短。
作者 赵强
出处 《海峡药学》 2013年第9期124-125,共2页 Strait Pharmaceutical Journal
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