摘要
目的探讨氟比洛芬酯联合吗啡镇痛对胃癌根治术患者术后吗啡用药量及肠功能恢复的影响。方法将府谷县人民医院2010年2月至2016年6月期间收治的98例胃癌根治术患者根据随机数表法分为对照组和观察组,每组49例,对照组给予常规硬膜外吗啡自控镇痛泵镇痛,观察组则在对照组基础上于术前及术后24 h静脉注射氟比洛芬酯50 mg,比较两组患者治疗前及治疗后48 h疼痛视觉模拟评分(VAS)、Ramsay镇静评分、舒适度评分(BCS)、吗啡用量及肠功能恢复情况。结果治疗后48 h,观察组和对照组患者的VAS评分[(3.57±0.42)分vs(5.18±0.43)分]、吗啡用量[(56.32±1.28)mg vs(65.83±1.25)mg)]比较,观察组明显低于对照组,差异均具有统计学意义(P<0.05);而观察组和对照组Ramsay镇静评分[(3.59±0.33)分vs(2.46±0.31)分]和BCS评分[(3.83±0.33)分vs(2.29±0.31)分]比较,观察组明显高于对照组,差异均具有统计学意义(P<0.05);观察组和对照组患者术后肛门排气时间[(1.64±0.58)d vs(2.35±0.59)d]、恢复正常饮食时间[(1.48±0.53)d vs(5.39±0.52)d]、术后恶心呕吐发生率(12.2%vs 34.7%)比较,观察组明显少于或低于对照组,差异均具有统计学意义(P<0.05)。结论胃癌根治术采用氟比洛芬酯协同吗啡镇痛,可减少吗啡用量,达到相同镇痛效果的同时减轻不良反应,并有利于术后肠功能恢复。
Objective To investigate the effects of flurbiprofen axetil combined with morphine for analgesia on postoperative morphine dosage and intestinal function recovery in patients undergoing radical gastrectomy for gastric cancer. Methods A total of 98 patients who underwent radical gastrectomy for gastric cancer in the People＇s Hospital of Fugu County from February 2010 to June 2016 were divided into a control group（n=49） and an observation group（n=49） according to the random number table method. The control group received conventional epidural morphine analgesia via patient-controlled analgesia pumps, and the observation group received intravenous injection of flurbiprofen axetil 50 mg on the basis of the control group before and 24 h after surgery. The scores of visual analogue scale（VAS） for pain, Ramsay sedation scale（RSS） scores, Bruggemann comfort scale（BCS） scores, morphine dosage, and the recovery of intestinal function were compared between two groups before and 48 h after treatment. Results At 48 hours after treatment, the VAS score and morphine dosage in the observation group were significantly lower than those in the control group：（3.57 ±0.42） vs（5.18±0.43） and（56.32±1.28） mg vs（65.83±1.25） mg, respectively; both differences were statistically significant（P0.05）. At the same time, the RSS score and BCS score of the observation group were significantly higher than those of the control group：（3.59±0.33） vs（2.46±0.31） and（3.83±0.33） vs（2.29±0.31）, respectively; P〈0.05. The postoperative anal exhaust time, the time of postoperative resumption of normal diet, and the incidence of postoperative nausea and vomiting in the observation group were significantly less or lower than those in the control group：（1.64±0.58） days vs（2.35±0.59） days,（1.48±0.53） days vs（5.39±0.52） days, 12.2% vs 34.7%, respectively; all differences were statistically significant（P〈0.05）. Conclusion Radical treatment of gastric cancer using fl
作者
齐振兵
张卫东
任永乐
QI Zhen-bing;ZHANG Wei-dong;REN Yong-le(Department of Anesthesiology 1.Department of General Surgery;the People＇s Hospital of Fugu County,Fugu 719400,Shaanxi,CHINA)
出处
《海南医学》
CAS
2018年第17期2411-2413,共3页
Hainan Medical Journal
关键词
肠功能
氟比洛芬酯
胃癌
吗啡
Intestinal fimction
Flurbiprofen axetil
Gastric cancer
Morphine
