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低氧诱导因子-1与病理妊娠关系的研究进展 被引量：4

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摘要 妊娠常见并发症如妊娠高血压疾病、胎儿生长受限、妊娠糖尿病等的发病机制涉及多种因素,与遗传易感性、代谢紊乱、胎盘形成缺陷、氧化应激等密切相关,但具体机制尚未明确。近年来研究显示,这些病理妊娠的发病过程与低氧密切相关,而低氧诱导因子-1(HIF-1)在机体低氧中起着重要的转录调控作用,生理状况下HIF-1参与调节滋养层细胞相关的侵袭和分化过程,对胚胎及胎盘血管的发生及发育过程起着重要作用。在病理状态下HIF-1可通过调控其下游靶基因的转录参与滋养细胞、胎盘的发育和血管生成、细胞凋亡等过程,以适应低氧环境。探讨HIF-1的结构和功能的调节及其在病理妊娠发病中的作用,研究如何维持HIF-1的适度表达,可为防治相关病理妊娠提供新的思路。
作者 匡国芳 杨晓菊 宗丽莎
机构地区 青岛大学医学院附属医院产科
出处 《青岛大学医学院学报》 CAS 2013年第6期562-564,共3页 Acta Academiae Medicinae Qingdao Universitatis
关键词 低氧诱导因子 妊娠并发症 综述
分类号 R714.2 [医药卫生—妇产科学]
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参考文献14

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共引文献7

同被引文献28

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青岛大学医学院学报
2013年 第6期

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