摘要
视网膜色素上皮(retinal pigment epithelium,RPE)细胞在眼的发育和视觉功能中起着重要的作用,具有分泌生长因子、抗氧化、参与视循环代谢、维持血-视网膜屏障和吞噬视细胞脱落的外节盘膜等重要生理功能。RPE细胞的正常结构和功能为视网膜感光细胞的正常发育及功能发挥所必需,若RPE细胞出现结构或功能异常则会导致视网膜感光细胞功能受损、视网膜退化等疾病。鉴于其重要性,就RPE细胞的发育、正常结构和功能进行综述,为其相关眼科疾病的治疗提供一定的依据。
The retinal pigment epithelium （RPE） cells play important roles in eye development and visual functions. RPE cells have the functions of secreting growth factor, antioxidant, involving in metabolism of visual cycle, maintaining the blood-retinal barrier, phagoeytosis of detached photoreceptor outer segments and other physiological functions. RPE normality is essential for photoreeeptor development and normal functions, and defects in RPE cell structure or functions will cause photoreceptor dysfunction and retinal degeneration. Recent studies have revealed new insights into important roles of RPE cells in related eye diseases. In this viewpoint, we provide an overview of some of the current understanding of RPE normal structure and functions and their roles in the development of related eye diseases.
出处
《生命科学》
CSCD
2013年第9期878-885,共8页
Chinese Bulletin of Life Sciences
基金
浙江省自然科学基金项目(LQ13H120004)
关键词
视网膜病变
RPE
色素细胞
眼科
retinal degeneration
RPE
pigment cell
eye disease
