摘要
目的探讨血清降钙素原(PCT)对危重患者细菌感染的临床意义,分析PCT对患者预后评估价值。方法选取ICU中69例细菌感染患者,将其分为一般感染组37例、重症感染组32例,并以30例非感染者作为非感染组,应用电化学发光法测定其血清PCT,荧光流式细胞计数法测定外周血白细胞(WBC)计数和透射比浊法测定C反应蛋白(CRP)水平,结果作统计分析。结果一般感染组PCT、CRP、WBC阳性率分别为89.1%、91.9%、75.7%,明显低于重症感染组的96.9%、100.0%、87.5%(P<0.05);一般感染组、重症感染组分别与非感染组比较PCT浓度有显著增高(P<0.05),一般感染组和重症感染组患者的血清PCT水平均显著高于非感染组患者(P<0.05);重症感染组患者的血清PCT水平显著高于一般感染组患者(P<0.05);CRP、WBC在重症感染组与一般感染症组之间比较差异均无统计学意义,当感染得到控制后PCT浓度也随之下降。结论血清PCT检测作为全身细菌感染早期诊断指标,在危重患者细菌感染诊断和预后临床治疗中具有较高的特异性和敏感性。
OBJECTIVE To investigate the clinical significance of serum procalcitonin （PCT） in diagnosis of bacterial infections in critically ill patients and analyze the value of prognosis in evaluation of prognosis. METHODS Totally 69 cases of patients with bacterial infections in ICU were enrolled in the study and were divided into the general infection group with 37 cases and the severe infection group with 32 cases, and 30 cases of patients without infections were set as the control group, then the serum PCT was determined by electrochemical luminescence assay, the peripheral white blood cell （WBC） count was determined by fluorescence flow cytometry method, C-reactive protein （CRP） level was measured by turbidimetrie method, and the results were statistically analyzed. RESULTS The positive rates of the PCT, CRP, and WBC of the general infection group were respectively 89.1% ,91.9%, and 75.7%, significantly lower than 96.9% ,100.0%, and 87.5G of the severe infection group（P 〈0.05） ; as compared with the non-infection group, the PCT concentration of the general infection group and the severe infection group was significantly elevated （P〈0.05） ; the level of serum PCT of the severe infection group was signifi- cantly higher than that of the general infection group （P〈0.05） ; the difference in the CRP or WBC between the general infection group and the severe infection group was not significant, the PCT concentration descended when the infection was controlled. CONCLUSION Serum PCT can be used as an indicator for the early diagnosis of systemic bacterial infections, with high specificity and sensitivity in the diagnosis of bacterial infections in critically ill patients and in the clinical prognosis.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第18期4593-4595,共3页
Chinese Journal of Nosocomiology
基金
河南省科技攻关计划项目(092102310347)
关键词
降钙素原
C反应蛋白
外周血白细胞
Procalcitonin
C-reactive protein
Peripheral blood leukocyte
