摘要
目的探讨在AECOPD抗感染治疗中监测PCT的价值。方法检索万方数据库、中国期刊全文数据库。纳入研究组为PCT指导组的临床随机对照试验。结果共纳入6个研究,Meta分析结果表明,以血清PCT含量0.25μg/L作为启用或停用抗菌药物的截断点可显著减少抗菌药物的使用;而且与常规治疗比较,疗效无显著差异。结论以血清PCT含量0.25μg/L作为AECOPD患者启用或停用抗菌药物的截断点可以在临床推广应用。
Objective To investigate the effects of anti-infective therapy in acute exacerbations of chronic ob-structive pulmonary disease（AECOPD）monitored with procalcitonin（PCT）. Methods China Academic Journals in Wanfang Database were searched. Studies with PCT as experimental parameter in randomized controlled trial were in-cluded in Meta-analysis. Results In six studies, antibiotics were significantly reduced after using serum PCT levels 0. 25 μg/L as truncation point. Efficacy had no significant difference in comparison with the conventional treatment. Conclusion Serum PCT levels 0. 25 μg/L in patients with AECOPD is a cut-off point for application of antibiotics.
出处
《实用药物与临床》
CAS
2014年第11期1406-1409,共4页
Practical Pharmacy and Clinical Remedies
基金
广州市医药卫生科技项目(20132A011021)
关键词
慢性阻塞性肺疾病急性加重期
降钙素原
META分析
Acute exacerbations of chronic obstructive pulmonary disease
Procalcitonin
Meta-analysis
